Persistent NRG1 Type III Overexpression in Spinal Motor Neurons Has No Therapeutic Effect on ALS-Related Pathology in SOD1(G93A) Mice

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons (MNs). Neuregulin-1 (NRG1) is a pleiotropic growth factor that has been shown to be potentially valuable for ALS when supplemented by means of viral-mediated gene therapy. However,...

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Detalles Bibliográficos
Autores principales: Hernández, Sara, Salvany, Sara, Casanovas, Anna, Piedrafita, Lídia, Soto-Bernardini, M. Clara, Tarabal, Olga, Blasco, Alba, Gras, Sílvia, Gatius, Alaó, Schwab, Markus H., Calderó, Jordi, Esquerda, Josep E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684470/
https://www.ncbi.nlm.nih.gov/pubmed/37733208
http://dx.doi.org/10.1007/s13311-023-01424-x

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