Cargando…

Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production

Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with broad applications. Here, we present the development of a yeast consortium for efficient production of (S)-norcoclaurine, the key precursor for benzylisoquinoline alkaloid biosynthesis. A xylose transporter enable...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Meirong, Zhao, Yuxin, Yao, Zhanyi, Su, Qianhe, Van Beek, Payton, Shao, Zengyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684500/ https://www.ncbi.nlm.nih.gov/pubmed/38016984 http://dx.doi.org/10.1038/s41467-023-43049-w

Ejemplares similares

Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus
por: Menéndez-Perdomo, Ivette M., et al.
Publicado: (2018)

BIAdb: A curated database of benzylisoquinoline alkaloids
por: Singla, Deepak, et al.
Publicado: (2010)

Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids
por: Ghirga, Francesca, et al.
Publicado: (2017)

Role of the phloem in the biochemistry and ecophysiology of benzylisoquinoline alkaloid metabolism
por: Lee, Eun-Jeong, et al.
Publicado: (2013)

Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases
por: Morris, Jeremy S., et al.
Publicado: (2019)

Engineering Saccharomyces cerevisiae to produce plant benzylisoquinoline alkaloids
por: Han, Jianing, et al.
Publicado: (2021)

Yarrowia lipolytica chassis strains engineered to produce aromatic amino acids via the shikimate pathway
por: Larroude, Macarena, et al.
Publicado: (2020)

Hairy root induction and benzylisoquinoline alkaloid production in Macleaya cordata
por: Huang, Peng, et al.
Publicado: (2018)

Corrigendum: Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases
por: Morris, Jeremy S., et al.
Publicado: (2019)

Rational Engineering of (S)-Norcoclaurine Synthase for Efficient Benzylisoquinoline Alkaloids Biosynthesis
por: De Sousa, João P. M., et al.
Publicado: (2023)

Visualization and identification of benzylisoquinoline alkaloids in various nelumbo nucifera tissues
por: Hao, Chenyang, et al.
Publicado: (2023)

Endophytic Consortium With Diverse Gene-Regulating Capabilities of Benzylisoquinoline Alkaloids Biosynthetic Pathway Can Enhance Endogenous Morphine Biosynthesis in Papaver somniferum
por: Ray, Tania, et al.
Publicado: (2019)

Biocatalytic Organic Synthesis of Optically Pure (S)-Scoulerine and Berbine and Benzylisoquinoline Alkaloids
por: Schrittwieser, Joerg H., et al.
Publicado: (2011)

Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants
por: Hagel, Jillian M., et al.
Publicado: (2015)

Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants
por: Hagel, Jillian M., et al.
Publicado: (2015)

Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species
por: He, Si-Mei, et al.
Publicado: (2018)

Investigation of benzylisoquinoline alkaloid biosynthetic pathway and its transcriptional regulation in lotus
por: Deng, Xianbao, et al.
Publicado: (2018)

The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids
por: Huang, Peng, et al.
Publicado: (2018)

Benzylisoquinoline Alkaloids from the Stems of Limacia scandens and Their Potential as Autophagy Inhibitors
por: Lee, Hee-Ju, et al.
Publicado: (2022)

De novo biosynthesis of berberine and halogenated benzylisoquinoline alkaloids in Saccharomyces cerevisiae
por: Han, Jianing, et al.
Publicado: (2023)

Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge enzyme in Macleaya cordata
por: Huang, Peng, et al.
Publicado: (2018)

Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo
por: Dong, Shijuan, et al.
Publicado: (2022)

The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants
por: Inoue, Naomi, et al.
Publicado: (2021)

Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants
por: Wang, Yu, et al.
Publicado: (2022)

Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)
por: Menéndez-Perdomo, Ivette M., et al.
Publicado: (2023)

Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus by Disrupting Virus Entry
por: Zhang, Caisheng, et al.
Publicado: (2023)

Balance of XYL1 and XYL2 expression in different yeast chassis for improved xylose fermentation
por: Zha, Jian, et al.
Publicado: (2012)

Metasecretome analysis of a lignocellulolytic microbial consortium grown on wheat straw, xylan and xylose
por: Jiménez, Diego Javier, et al.
Publicado: (2015)

Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate
por: Fujiwara, Ryosuke, et al.
Publicado: (2020)

Construction of microbial chassis for terpenoid discovery
por: Zhai, Xiaoxin, et al.
Publicado: (2022)

Tyrosine phosphorylation and protein degradation control the transcriptional activity of WRKY involved in benzylisoquinoline alkaloid biosynthesis
por: Yamada, Yasuyuki, et al.
Publicado: (2016)

Modulation of benzylisoquinoline alkaloid biosynthesis by heterologous expression of CjWRKY1 in Eschscholzia californica cells
por: Yamada, Yasuyuki, et al.
Publicado: (2017)

Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
por: Vavricka, Christopher J., et al.
Publicado: (2019)

Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids
por: Bu, Junling, et al.
Publicado: (2022)

Synthetic promoter design for new microbial chassis
por: Gilman, James, et al.
Publicado: (2016)

Streptomyces as Microbial Chassis for Heterologous Protein Expression
por: Hwang, Soonkyu, et al.
Publicado: (2021)

Engineering of an endogenous hexose transporter into a specific D-xylose transporter facilitates glucose-xylose co-consumption in Saccharomyces cerevisiae
por: Nijland, Jeroen G, et al.
Publicado: (2014)

Evolutionary origin of the NCSI gene subfamily encoding norcoclaurine synthase is associated with the biosynthesis of benzylisoquinoline alkaloids in plants
por: Vimolmangkang, Sornkanok, et al.
Publicado: (2016)

Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo
por: Xu, Dingqiao, et al.
Publicado: (2021)

Chromosome-level genome assembly of Aristolochia contorta provides insights into the biosynthesis of benzylisoquinoline alkaloids and aristolochic acids
por: Cui, Xinyun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sl7bab191u5u9jpf7497s5lh3g