CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscure. Here, we find increased expression of the C(16:0) cerami...

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Detalles Bibliográficos
Autores principales: Hammerschmidt, Philipp, Steculorum, Sophie M., Bandet, Cécile L., Del Río-Martín, Almudena, Steuernagel, Lukas, Kohlhaas, Vivien, Feldmann, Marvin, Varela, Luis, Majcher, Adam, Quatorze Correia, Marta, Klar, Rhena F. U., Bauder, Corinna A., Kaya, Ecem, Porniece, Marta, Biglari, Nasim, Sieben, Anna, Horvath, Tamas L., Hornemann, Thorsten, Brodesser, Susanne, Brüning, Jens C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684560/
https://www.ncbi.nlm.nih.gov/pubmed/38016943
http://dx.doi.org/10.1038/s41467-023-42595-7

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