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Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease

Evidence regarding the association between physical activity and Parkinson’s disease (PD) risk is generally limited due to the use of self-report questionnaires. We aimed to quantify the separate and combined effects of accelerometer-measured light physical activity (LPA), moderate-to-vigorous physi...

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Autores principales: Liu, Mengyi, Gan, Xiaoqin, Ye, Ziliang, Zhang, Yuanyuan, He, Panpan, Zhou, Chun, Yang, Sisi, Zhang, Yanjun, Qin, Xianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684568/
https://www.ncbi.nlm.nih.gov/pubmed/38017114
http://dx.doi.org/10.1038/s41746-023-00969-7
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author Liu, Mengyi
Gan, Xiaoqin
Ye, Ziliang
Zhang, Yuanyuan
He, Panpan
Zhou, Chun
Yang, Sisi
Zhang, Yanjun
Qin, Xianhui
author_facet Liu, Mengyi
Gan, Xiaoqin
Ye, Ziliang
Zhang, Yuanyuan
He, Panpan
Zhou, Chun
Yang, Sisi
Zhang, Yanjun
Qin, Xianhui
author_sort Liu, Mengyi
collection PubMed
description Evidence regarding the association between physical activity and Parkinson’s disease (PD) risk is generally limited due to the use of self-report questionnaires. We aimed to quantify the separate and combined effects of accelerometer-measured light physical activity (LPA), moderate-to-vigorous physical activity (MVPA), sedentary time and exercise timing with incident PD. 96,422 participants without prior PD and with usable accelerometer data were included from UK Biobank. Time spent in sedentary activity, LPA, MVPA, and exercise timing were estimated using machine learning models. The study outcome was incident PD. Over a median follow-up duration of 6.8 years, 313 participants developed PD. There was a L-shaped association for LPA and MVPA, and a reversed L-shaped association for sedentary time, with the risk of incident PD (all P for nonlinearity < 0.001). Similar trends were found across three time-windows (morning, midday-afternoon, and evening). Compared with those with both low LPA (<3.89 h/day) and low MVPA (<0.27 h/day), the adjusted HR (95% CI) of PD risk was 0.49 (0.36–0.66), 0.19 (0.36–0.66) and 0.13 (0.09–0.18), respectively, for participants with high MVPA only, high LPA only, and both high LPA and high MVPA. Moreover, participants with both low LPA and high sedentary time (≥9.41 h/day) (adjusted HR, 5.59; 95% CI: 4.10–7.61), and those with both low MVPA and high sedentary time (adjusted HR, 3.93; 95% CI: 2.82–5.49) had the highest risk of incident PD. In conclusion, regardless of exercise timing (morning, midday-afternoon, and evening), there was an inverse association for accelerometer-measured MVPA and LPA, and a positive association for sedentary time, with incident PD.
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spelling pubmed-106845682023-11-30 Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease Liu, Mengyi Gan, Xiaoqin Ye, Ziliang Zhang, Yuanyuan He, Panpan Zhou, Chun Yang, Sisi Zhang, Yanjun Qin, Xianhui NPJ Digit Med Article Evidence regarding the association between physical activity and Parkinson’s disease (PD) risk is generally limited due to the use of self-report questionnaires. We aimed to quantify the separate and combined effects of accelerometer-measured light physical activity (LPA), moderate-to-vigorous physical activity (MVPA), sedentary time and exercise timing with incident PD. 96,422 participants without prior PD and with usable accelerometer data were included from UK Biobank. Time spent in sedentary activity, LPA, MVPA, and exercise timing were estimated using machine learning models. The study outcome was incident PD. Over a median follow-up duration of 6.8 years, 313 participants developed PD. There was a L-shaped association for LPA and MVPA, and a reversed L-shaped association for sedentary time, with the risk of incident PD (all P for nonlinearity < 0.001). Similar trends were found across three time-windows (morning, midday-afternoon, and evening). Compared with those with both low LPA (<3.89 h/day) and low MVPA (<0.27 h/day), the adjusted HR (95% CI) of PD risk was 0.49 (0.36–0.66), 0.19 (0.36–0.66) and 0.13 (0.09–0.18), respectively, for participants with high MVPA only, high LPA only, and both high LPA and high MVPA. Moreover, participants with both low LPA and high sedentary time (≥9.41 h/day) (adjusted HR, 5.59; 95% CI: 4.10–7.61), and those with both low MVPA and high sedentary time (adjusted HR, 3.93; 95% CI: 2.82–5.49) had the highest risk of incident PD. In conclusion, regardless of exercise timing (morning, midday-afternoon, and evening), there was an inverse association for accelerometer-measured MVPA and LPA, and a positive association for sedentary time, with incident PD. Nature Publishing Group UK 2023-11-28 /pmc/articles/PMC10684568/ /pubmed/38017114 http://dx.doi.org/10.1038/s41746-023-00969-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Liu, Mengyi
Gan, Xiaoqin
Ye, Ziliang
Zhang, Yuanyuan
He, Panpan
Zhou, Chun
Yang, Sisi
Zhang, Yanjun
Qin, Xianhui
Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease
title Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease
title_full Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease
title_fullStr Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease
title_full_unstemmed Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease
title_short Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease
title_sort association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684568/
https://www.ncbi.nlm.nih.gov/pubmed/38017114
http://dx.doi.org/10.1038/s41746-023-00969-7
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