Cargando…

NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease

Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To evalu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Berven, Haakon, Kverneng, Simon, Sheard, Erika, Søgnen, Mona, Af Geijerstam, Solveig Amdahl, Haugarvoll, Kristoffer, Skeie, Geir-Olve, Dölle, Christian, Tzoulis, Charalampos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684646/ https://www.ncbi.nlm.nih.gov/pubmed/38016950 http://dx.doi.org/10.1038/s41467-023-43514-6

Ejemplares similares

Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson’s disease
por: Gaare, Johannes J., et al.
Publicado: (2023)

NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health
por: Alegre, Gabriela Fabiana Soares, et al.
Publicado: (2023)

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells
por: Fletcher, Rachel S., et al.
Publicado: (2017)

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD(+) by Generating Dihydronicotinamide Riboside
por: Ciarlo, Eleonora, et al.
Publicado: (2022)

Dihydronicotinamide riboside: synthesis from nicotinamide riboside chloride, purification and stability studies
por: Zarei, Amin, et al.
Publicado: (2021)

A nationwide study of the incidence, prevalence and mortality of Parkinson’s disease in the Norwegian population
por: Brakedal, Brage, et al.
Publicado: (2022)

The Clinical Effects of Nicotinamide Riboside on Inflammatory Parameters
por: Kwon, Jun, et al.
Publicado: (2022)

Emerging Role of Nicotinamide Riboside in Health and Diseases
por: Sharma, Chiranjeev, et al.
Publicado: (2022)

Glitazone use associated with reduced risk of Parkinson's disease
por: Brakedal, Brage, et al.
Publicado: (2017)

NSAID use is not associated with Parkinson’s disease incidence: A Norwegian Prescription Database study
por: Brakedal, Brage, et al.
Publicado: (2021)

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
por: Ratajczak, Joanna, et al.
Publicado: (2016)

Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells
por: Kropotov, Andrey, et al.
Publicado: (2021)

Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci
por: Gaare, Johannes Jernqvist, et al.
Publicado: (2020)

ODP205 Hepatic steatosis induced by Nicotine plus Coca Cola is prevented by Nicotinamide riboside (NR) that increases mitochondrial NAD+
por: Friedman, Theodore C, et al.
Publicado: (2022)

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
por: Trammell, Samuel A. J., et al.
Publicado: (2016)

The emergence of the nicotinamide riboside kinases in the regulation of NAD(+) metabolism
por: Fletcher, Rachel S, et al.
Publicado: (2018)

Nicotinamide Riboside—The Current State of Research and Therapeutic Uses
por: Mehmel, Mario, et al.
Publicado: (2020)

The effects of in ovo nicotinamide riboside dose on broiler myogenesis
por: Xu, Xiaoxing, et al.
Publicado: (2020)

New Crystalline Salts of Nicotinamide Riboside as Food Additives
por: Schabert, Günter, et al.
Publicado: (2021)

Synthesis, Stability, and Bioavailability of Nicotinamide Riboside Trioleate Chloride
por: Zarei, Amin, et al.
Publicado: (2021)

Nicotinamide Riboside Supports Brain Health: Assessing the Evidence
por: Nkrumah-Elie, Yasmeen, et al.
Publicado: (2022)

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain
por: Toker, Lilah, et al.
Publicado: (2021)

Nicotinamide, Nicotinamide Riboside and Nicotinic Acid—Emerging Roles in Replicative and Chronological Aging in Yeast
por: Orlandi, Ivan, et al.
Publicado: (2020)

Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+)
por: Tempel, Wolfram, et al.
Publicado: (2007)

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice
por: Trammell, Samuel A.J., et al.
Publicado: (2016)

The NAD(+) precursor nicotinamide riboside decreases exercise performance in rats
por: Kourtzidis, Ioannis A., et al.
Publicado: (2016)

Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects
por: Podyacheva, Ekaterina, et al.
Publicado: (2021)

Balancing NAD(+) deficits with nicotinamide riboside: therapeutic possibilities and limitations
por: Cercillieux, Angelique, et al.
Publicado: (2022)

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers
por: Airhart, Sophia E., et al.
Publicado: (2017)

The senotherapeutic nicotinamide riboside raises platelet nicotinamide adenine dinucleotide levels but cannot prevent storage lesion
por: Delabie, Willem, et al.
Publicado: (2019)

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives
por: Makarov, Mikhail V, et al.
Publicado: (2019)

Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes
por: Lee, Hee Jae, et al.
Publicado: (2019)

SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside
por: Mukherjee, Sarmistha, et al.
Publicado: (2021)

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD
por: Sverkeli, Lars Jansen, et al.
Publicado: (2021)

Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice
por: Schaefer, Patrick M., et al.
Publicado: (2022)

Nicotinamide Riboside Improves Ataxia Scores and Immunoglobulin Levels in Ataxia Telangiectasia
por: Veenhuis, Stefanie J.G., et al.
Publicado: (2021)

Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
por: Kropotov, Andrey, et al.
Publicado: (2022)

Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats
por: Selli, Jale, et al.
Publicado: (2023)

SUPPLEMENTATION WITH NICOTINAMIDE RIBOSIDE ATTENUATES T CELL EXHAUSTION AND IMPROVES SURVIVAL IN SEPSIS
por: Zhao, Guang-ju, et al.
Publicado: (2023)

What is really known about the effects of nicotinamide riboside supplementation in humans
por: Damgaard, Mads V., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_if9d3a4vaebder30ftm70j8dn4