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Immunomodulatory roles of metalloproteinases in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic, autoimmune pathology characterized by persistent synovial inflammation and gradually advancing bone destruction. Matrix metalloproteinases (MMPs), as a family of zinc-containing enzymes, have been found to play an important role in degradation and remodeling o...

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Autores principales: Bian, Yanqin, Xiang, Zheng, Wang, Yaofeng, Ren, Qing, Chen, Guoming, Xiang, Bei, Wang, Jianye, Zhang, Chengbo, Pei, Shaoqiang, Guo, Shicheng, Xiao, Lianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684723/
https://www.ncbi.nlm.nih.gov/pubmed/38035026
http://dx.doi.org/10.3389/fphar.2023.1285455
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author Bian, Yanqin
Xiang, Zheng
Wang, Yaofeng
Ren, Qing
Chen, Guoming
Xiang, Bei
Wang, Jianye
Zhang, Chengbo
Pei, Shaoqiang
Guo, Shicheng
Xiao, Lianbo
author_facet Bian, Yanqin
Xiang, Zheng
Wang, Yaofeng
Ren, Qing
Chen, Guoming
Xiang, Bei
Wang, Jianye
Zhang, Chengbo
Pei, Shaoqiang
Guo, Shicheng
Xiao, Lianbo
author_sort Bian, Yanqin
collection PubMed
description Rheumatoid arthritis (RA) is a chronic, autoimmune pathology characterized by persistent synovial inflammation and gradually advancing bone destruction. Matrix metalloproteinases (MMPs), as a family of zinc-containing enzymes, have been found to play an important role in degradation and remodeling of extracellular matrix (ECM). MMPs participate in processes of cell proliferation, migration, inflammation, and cell metabolism. A growing number of persons have paid attention to their function in inflammatory and immune diseases. In this review, the details of regulation of MMPs expression and its expression in RA are summarized. The role of MMPs in ECM remodeling, angiogenesis, oxidative and nitrosative stress, cell migration and invasion, cytokine and chemokine production, PANoptosis and bone destruction in RA disease are discussed. Additionally, the review summarizes clinical trials targeting MMPs in inflammatory disease and discusses the potential of MMP inhibition in the therapeutic context of RA. MMPs may serve as biomarkers for drug response, pathology stratification, and precision medicine to improve clinical management of rheumatoid arthritis.
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spelling pubmed-106847232023-11-30 Immunomodulatory roles of metalloproteinases in rheumatoid arthritis Bian, Yanqin Xiang, Zheng Wang, Yaofeng Ren, Qing Chen, Guoming Xiang, Bei Wang, Jianye Zhang, Chengbo Pei, Shaoqiang Guo, Shicheng Xiao, Lianbo Front Pharmacol Pharmacology Rheumatoid arthritis (RA) is a chronic, autoimmune pathology characterized by persistent synovial inflammation and gradually advancing bone destruction. Matrix metalloproteinases (MMPs), as a family of zinc-containing enzymes, have been found to play an important role in degradation and remodeling of extracellular matrix (ECM). MMPs participate in processes of cell proliferation, migration, inflammation, and cell metabolism. A growing number of persons have paid attention to their function in inflammatory and immune diseases. In this review, the details of regulation of MMPs expression and its expression in RA are summarized. The role of MMPs in ECM remodeling, angiogenesis, oxidative and nitrosative stress, cell migration and invasion, cytokine and chemokine production, PANoptosis and bone destruction in RA disease are discussed. Additionally, the review summarizes clinical trials targeting MMPs in inflammatory disease and discusses the potential of MMP inhibition in the therapeutic context of RA. MMPs may serve as biomarkers for drug response, pathology stratification, and precision medicine to improve clinical management of rheumatoid arthritis. Frontiers Media S.A. 2023-11-15 /pmc/articles/PMC10684723/ /pubmed/38035026 http://dx.doi.org/10.3389/fphar.2023.1285455 Text en Copyright © 2023 Bian, Xiang, Wang, Ren, Chen, Xiang, Wang, Zhang, Pei, Guo and Xiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Bian, Yanqin
Xiang, Zheng
Wang, Yaofeng
Ren, Qing
Chen, Guoming
Xiang, Bei
Wang, Jianye
Zhang, Chengbo
Pei, Shaoqiang
Guo, Shicheng
Xiao, Lianbo
Immunomodulatory roles of metalloproteinases in rheumatoid arthritis
title Immunomodulatory roles of metalloproteinases in rheumatoid arthritis
title_full Immunomodulatory roles of metalloproteinases in rheumatoid arthritis
title_fullStr Immunomodulatory roles of metalloproteinases in rheumatoid arthritis
title_full_unstemmed Immunomodulatory roles of metalloproteinases in rheumatoid arthritis
title_short Immunomodulatory roles of metalloproteinases in rheumatoid arthritis
title_sort immunomodulatory roles of metalloproteinases in rheumatoid arthritis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684723/
https://www.ncbi.nlm.nih.gov/pubmed/38035026
http://dx.doi.org/10.3389/fphar.2023.1285455
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