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High number of seizures and unconsciousness in patients with SARS-CoV-2 omicron variants: a retrospective study

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variants are now a pandemic. There are differences in clinical features in SARS-CoV-2 variants and we conducted this study to assess the clinical features of coronavirus disease (COVID-19) in children with SARS-CoV-2 omicron varian...

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Autores principales: Tokuyama, Kishin, Kitamura, Tsubasa, Maruyama, Kazutaka, Toriumi, Shun, Murano, Yayoi, Yoneoka, Daisuke, Nakazawa, Tomoyuki, Shimizu, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684743/
https://www.ncbi.nlm.nih.gov/pubmed/38034823
http://dx.doi.org/10.3389/fped.2023.1273464
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author Tokuyama, Kishin
Kitamura, Tsubasa
Maruyama, Kazutaka
Toriumi, Shun
Murano, Yayoi
Yoneoka, Daisuke
Nakazawa, Tomoyuki
Shimizu, Toshiaki
author_facet Tokuyama, Kishin
Kitamura, Tsubasa
Maruyama, Kazutaka
Toriumi, Shun
Murano, Yayoi
Yoneoka, Daisuke
Nakazawa, Tomoyuki
Shimizu, Toshiaki
author_sort Tokuyama, Kishin
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variants are now a pandemic. There are differences in clinical features in SARS-CoV-2 variants and we conducted this study to assess the clinical features of coronavirus disease (COVID-19) in children with SARS-CoV-2 omicron variants. The study included children with COVID-19 arrivedto Tokyo Metropolitan Toshima Hospital between January 2020 and October 2022. The clinical features of 214 children with SARS-CoV-2 non-omicron variants and 557 children with omicron variants were compared. In the SARS-CoV-2 omicron variant group, more patients had fever, sore throat, nausea and/or vomiting, and seizures and/or disorders of consciousness. In SARS-CoV-2 non-omicron variants, there was only one patient with seizure and/or unconsciousness whereas there were 92 children in omicron variants. Among these 92 patients, 46 (49%) were diagnosed with simple febrile seizures; 23 (25%), with complex febrile seizures; 10 (11%) with status epilepticus; and two (2%) with encephalopathy. Their mean age was 4.0 ± 3.0 years—a wider age distribution than that in other febrile seizures but similar to that in febrile seizures in patients with influenza. SARS-CoV-2 omicron variants are likely to cause seizures and unconsciousness in children and their age distribution was wider than other febrile seizures patients but similar to those in influenza patients. In clinical practice in patients with COVID-19 and influenza, clinicians should be aware of these features.
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spelling pubmed-106847432023-11-30 High number of seizures and unconsciousness in patients with SARS-CoV-2 omicron variants: a retrospective study Tokuyama, Kishin Kitamura, Tsubasa Maruyama, Kazutaka Toriumi, Shun Murano, Yayoi Yoneoka, Daisuke Nakazawa, Tomoyuki Shimizu, Toshiaki Front Pediatr Pediatrics Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variants are now a pandemic. There are differences in clinical features in SARS-CoV-2 variants and we conducted this study to assess the clinical features of coronavirus disease (COVID-19) in children with SARS-CoV-2 omicron variants. The study included children with COVID-19 arrivedto Tokyo Metropolitan Toshima Hospital between January 2020 and October 2022. The clinical features of 214 children with SARS-CoV-2 non-omicron variants and 557 children with omicron variants were compared. In the SARS-CoV-2 omicron variant group, more patients had fever, sore throat, nausea and/or vomiting, and seizures and/or disorders of consciousness. In SARS-CoV-2 non-omicron variants, there was only one patient with seizure and/or unconsciousness whereas there were 92 children in omicron variants. Among these 92 patients, 46 (49%) were diagnosed with simple febrile seizures; 23 (25%), with complex febrile seizures; 10 (11%) with status epilepticus; and two (2%) with encephalopathy. Their mean age was 4.0 ± 3.0 years—a wider age distribution than that in other febrile seizures but similar to that in febrile seizures in patients with influenza. SARS-CoV-2 omicron variants are likely to cause seizures and unconsciousness in children and their age distribution was wider than other febrile seizures patients but similar to those in influenza patients. In clinical practice in patients with COVID-19 and influenza, clinicians should be aware of these features. Frontiers Media S.A. 2023-11-15 /pmc/articles/PMC10684743/ /pubmed/38034823 http://dx.doi.org/10.3389/fped.2023.1273464 Text en © 2023 Tokuyama, Kitamura, Maruyama, Toriumi, Murano, Yoneoka, Nakazawa and Shimizu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Tokuyama, Kishin
Kitamura, Tsubasa
Maruyama, Kazutaka
Toriumi, Shun
Murano, Yayoi
Yoneoka, Daisuke
Nakazawa, Tomoyuki
Shimizu, Toshiaki
High number of seizures and unconsciousness in patients with SARS-CoV-2 omicron variants: a retrospective study
title High number of seizures and unconsciousness in patients with SARS-CoV-2 omicron variants: a retrospective study
title_full High number of seizures and unconsciousness in patients with SARS-CoV-2 omicron variants: a retrospective study
title_fullStr High number of seizures and unconsciousness in patients with SARS-CoV-2 omicron variants: a retrospective study
title_full_unstemmed High number of seizures and unconsciousness in patients with SARS-CoV-2 omicron variants: a retrospective study
title_short High number of seizures and unconsciousness in patients with SARS-CoV-2 omicron variants: a retrospective study
title_sort high number of seizures and unconsciousness in patients with sars-cov-2 omicron variants: a retrospective study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684743/
https://www.ncbi.nlm.nih.gov/pubmed/38034823
http://dx.doi.org/10.3389/fped.2023.1273464
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