Cargando…

A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes

Acute inflammation is heterogeneous in critical illness and predictive of outcome. We hypothesized that genetic variability in novel, yet common, gene variants contributes to this heterogeneity and could stratify patient outcomes. We searched algorithmically for significant differences in systemic i...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Dehaibi, Fayten, Zamora, Ruben, Radder, Josiah, Yin, Jinling, Shah, Ashti M., Namas, Rami A., Situ, Michelle, Zhao, Yanwu, Bain, William, Morris, Alison, McVerry, Bryan J., Barclay, Derek A., Billiar, Timothy R., Zhang, Yingze, Kitsios, Georgios D., Vodovotz, Yoram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684809/ https://www.ncbi.nlm.nih.gov/pubmed/38034362 http://dx.doi.org/10.1016/j.isci.2023.108333

Ejemplares similares

Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling
por: Shah, Ashti M., et al.
Publicado: (2022)

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes
por: Schimunek, Lukas, et al.
Publicado: (2019)

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes
por: Schimunek, Lukas, et al.
Publicado: (2021)

“Thinking” vs. “Talking”: Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress
por: Vodovotz, Yoram, et al.
Publicado: (2017)

A putative “chemokine switch” that regulates systemic acute inflammation in humans
por: Azhar, Nabil, et al.
Publicado: (2021)

Peripheral nerve repair is associated with augmented cross-tissue inflammation following vascularized composite allotransplantation
por: Shah, Ashti M., et al.
Publicado: (2023)

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice
por: Namas, Rami A., et al.
Publicado: (2013)

The Effects of Tacrolimus on Tissue-Specific, Protein-Level Inflammatory Networks in Vascularized Composite Allotransplantation
por: Aral, Ali Mubin, et al.
Publicado: (2021)

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma
por: Zaaqoq, Akram M., et al.
Publicado: (2019)

Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies
por: Ziraldo, Cordelia, et al.
Publicado: (2013)

Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure
por: Vodovotz, Yoram, et al.
Publicado: (2021)

Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks
por: Sadowsky, David, et al.
Publicado: (2016)

The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical illness
por: Chen, Tianmeng, et al.
Publicado: (2022)

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen
por: Zamora, Ruben, et al.
Publicado: (2019)

Biomarker-Based Classification of Patients With Acute Respiratory Failure Into Inflammatory Subphenotypes: A Single-Center Exploratory Study
por: Drohan, Callie M., et al.
Publicado: (2021)

Inflammatory signals and network connections implicate cell-mediated immunity in chronic venous insufficiency
por: Vodovotz, Lena, et al.
Publicado: (2021)

Distinct profiles of host responses between plasma and lower respiratory tract during acute respiratory failure
por: Kitsios, Georgios D., et al.
Publicado: (2023)

Protective/reparative cytokines are suppressed at high injury severity in human trauma
por: Cai, Jinman, et al.
Publicado: (2021)

Defining spatiotemporal gene modules in liver regeneration using Analytical Dynamic Visual Spatial Omics Representation (ADViSOR)
por: Singh-Varma, Anya, et al.
Publicado: (2023)

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries
por: Almahmoud, Khalid, et al.
Publicado: (2019)

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients
por: Abdul-Malak, Othman, et al.
Publicado: (2016)

Plasma microbial cell-free DNA load is associated with mortality in patients with COVID-19
por: Kitsios, Georgios D., et al.
Publicado: (2021)

Insights into the association between coagulopathy and inflammation: abnormal clot mechanics are a warning of immunologic dysregulation following major injury
por: Savage, Stephanie A., et al.
Publicado: (2020)

A Dynamic View of Trauma/Hemorrhage-Induced Inflammation in Mice: Principal Drivers and Networks
por: Mi, Qi, et al.
Publicado: (2011)

The Acute Inflammatory Response in Trauma / Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects
por: Namas, R, et al.
Publicado: (2009)

Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients
por: Liu, Dongmei, et al.
Publicado: (2020)

Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill
por: Bonaroti, Jillian, et al.
Publicado: (2022)

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice
por: Zamora, Ruben, et al.
Publicado: (2018)

Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks
por: Zamora, Ruben, et al.
Publicado: (2021)

Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties
por: Zamora, Ruben, et al.
Publicado: (2023)

Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients
por: Kitsios, Georgios D., et al.
Publicado: (2023)

Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients
por: Kitsios, Georgios D., et al.
Publicado: (2023)

Time for trauma immunology
por: Billiar, Timothy R., et al.
Publicado: (2017)

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model
por: Xu, Jing, et al.
Publicado: (2017)

Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis
por: Tyagi, Pradeep, et al.
Publicado: (2009)

An Adequately Robust Early TNF-α Response Is a Hallmark of Survival Following Trauma/Hemorrhage
por: Namas, Rajaie, et al.
Publicado: (2009)

Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients
por: Farooq, Nauman, et al.
Publicado: (2021)

Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome
por: Suber, Tomeka L., et al.
Publicado: (2023)

Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia
por: Lai, Yandong, et al.
Publicado: (2021)

Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis
por: Lai, Yandong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nve2ssjnrtlvjme4lha6bddoh0