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Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study

This study aimed to analyze the infection risk factors for transurethral resection of the prostate (TURP) and establish predictive models to help make personalized treatment plans. Our study was designed one-center and retrospectively enrolled 1169 benign prostatic hyperplasia (BPH) patients. Risk f...

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Autores principales: Lin, Jiexiang, Yang, Zesong, Ye, Liefu, Hong, Yun, Cai, Wanghai, Pan, Honghong, Fu, Haishou, Wu, Jinfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684857/
https://www.ncbi.nlm.nih.gov/pubmed/38016988
http://dx.doi.org/10.1038/s41598-023-47773-7
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author Lin, Jiexiang
Yang, Zesong
Ye, Liefu
Hong, Yun
Cai, Wanghai
Pan, Honghong
Fu, Haishou
Wu, Jinfeng
author_facet Lin, Jiexiang
Yang, Zesong
Ye, Liefu
Hong, Yun
Cai, Wanghai
Pan, Honghong
Fu, Haishou
Wu, Jinfeng
author_sort Lin, Jiexiang
collection PubMed
description This study aimed to analyze the infection risk factors for transurethral resection of the prostate (TURP) and establish predictive models to help make personalized treatment plans. Our study was designed one-center and retrospectively enrolled 1169 benign prostatic hyperplasia (BPH) patients. Risk factors were explored for postoperative infection. A TURP-postoperative infection (TURP-PI) model with infection prediction values was created. The improved-TURP-PI (I-TURP-PI) model, including extra new factors (pathogens species), was also built to see whether it could optimize the prediction abilities. At last, we developed a nomogram for better clinical application. Operation time, preoperative indwelling urinary catheter (PIUC), and positive preoperative urine culture were independent risk factors (all P < 0.05). Interestingly, pathogens species in pre-surgery urine (P(Enterococcus faecium) = 0.014, P(Pseudomonas aeruginosa) = 0.086) were also independent risk factors. Patients with positive Enterococcus faecium (37.50%) were most likely to have postoperative infection. We built two models with AUC(TURP-PI) = 0.709 (95% CI 0.656–0.763) and AUC(I-TURP-PI) = 0.705 (95% CI 0.650–0.760). The nomogram could help improve the prediction ability. To our knowledge, our study is the first to use pathogen species in urine before surgery as risk factors for infection prediction after TURP. TURP-PI and I-TURP-PI models have essential roles in predicting patients' postoperative infections and in better postoperative antibiotic decision-making.
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spelling pubmed-106848572023-11-30 Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study Lin, Jiexiang Yang, Zesong Ye, Liefu Hong, Yun Cai, Wanghai Pan, Honghong Fu, Haishou Wu, Jinfeng Sci Rep Article This study aimed to analyze the infection risk factors for transurethral resection of the prostate (TURP) and establish predictive models to help make personalized treatment plans. Our study was designed one-center and retrospectively enrolled 1169 benign prostatic hyperplasia (BPH) patients. Risk factors were explored for postoperative infection. A TURP-postoperative infection (TURP-PI) model with infection prediction values was created. The improved-TURP-PI (I-TURP-PI) model, including extra new factors (pathogens species), was also built to see whether it could optimize the prediction abilities. At last, we developed a nomogram for better clinical application. Operation time, preoperative indwelling urinary catheter (PIUC), and positive preoperative urine culture were independent risk factors (all P < 0.05). Interestingly, pathogens species in pre-surgery urine (P(Enterococcus faecium) = 0.014, P(Pseudomonas aeruginosa) = 0.086) were also independent risk factors. Patients with positive Enterococcus faecium (37.50%) were most likely to have postoperative infection. We built two models with AUC(TURP-PI) = 0.709 (95% CI 0.656–0.763) and AUC(I-TURP-PI) = 0.705 (95% CI 0.650–0.760). The nomogram could help improve the prediction ability. To our knowledge, our study is the first to use pathogen species in urine before surgery as risk factors for infection prediction after TURP. TURP-PI and I-TURP-PI models have essential roles in predicting patients' postoperative infections and in better postoperative antibiotic decision-making. Nature Publishing Group UK 2023-11-28 /pmc/articles/PMC10684857/ /pubmed/38016988 http://dx.doi.org/10.1038/s41598-023-47773-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lin, Jiexiang
Yang, Zesong
Ye, Liefu
Hong, Yun
Cai, Wanghai
Pan, Honghong
Fu, Haishou
Wu, Jinfeng
Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study
title Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study
title_full Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study
title_fullStr Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study
title_full_unstemmed Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study
title_short Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study
title_sort pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684857/
https://www.ncbi.nlm.nih.gov/pubmed/38016988
http://dx.doi.org/10.1038/s41598-023-47773-7
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