Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo

Several observational studies have demonstrated a consistent pattern of decreased melanoma risk among patients with vitiligo. More recently, this finding has been supported by a suggested genetic relationship between the two entities, with certain variants significantly associated with an increased...

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Detalles Bibliográficos
Autores principales: Rashid, Sarem, Molotkov, Ivan, Klebanov, Nikolai, Shaughnessy, Michael, Daly, Mark J., Artomov, Mykyta, Tsao, Hensin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685305/
https://www.ncbi.nlm.nih.gov/pubmed/38034848
http://dx.doi.org/10.1016/j.xjidi.2023.100217
Descripción
Sumario:Several observational studies have demonstrated a consistent pattern of decreased melanoma risk among patients with vitiligo. More recently, this finding has been supported by a suggested genetic relationship between the two entities, with certain variants significantly associated with an increased risk of melanoma, basal cell carcinoma, and squamous cell carcinoma but a decreased risk of vitiligo. We compared 48 associated variants from a recently published GWAS and identified three variants—located in the TYR, MC1R-DEF8, and RALY-EIF2S2-ASIP-AHCY-ITCH

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