Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo

Several observational studies have demonstrated a consistent pattern of decreased melanoma risk among patients with vitiligo. More recently, this finding has been supported by a suggested genetic relationship between the two entities, with certain variants significantly associated with an increased...

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Detalles Bibliográficos
Autores principales: Rashid, Sarem, Molotkov, Ivan, Klebanov, Nikolai, Shaughnessy, Michael, Daly, Mark J., Artomov, Mykyta, Tsao, Hensin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685305/
https://www.ncbi.nlm.nih.gov/pubmed/38034848
http://dx.doi.org/10.1016/j.xjidi.2023.100217
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author Rashid, Sarem
Molotkov, Ivan
Klebanov, Nikolai
Shaughnessy, Michael
Daly, Mark J.
Artomov, Mykyta
Tsao, Hensin
author_facet Rashid, Sarem
Molotkov, Ivan
Klebanov, Nikolai
Shaughnessy, Michael
Daly, Mark J.
Artomov, Mykyta
Tsao, Hensin
author_sort Rashid, Sarem
collection PubMed
description Several observational studies have demonstrated a consistent pattern of decreased melanoma risk among patients with vitiligo. More recently, this finding has been supported by a suggested genetic relationship between the two entities, with certain variants significantly associated with an increased risk of melanoma, basal cell carcinoma, and squamous cell carcinoma but a decreased risk of vitiligo. We compared 48 associated variants from a recently published GWAS and identified three variants—located in the TYR, MC1R-DEF8, and RALY-EIF2S2-ASIP-AHCY-ITCH
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spelling pubmed-106853052023-11-30 Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo Rashid, Sarem Molotkov, Ivan Klebanov, Nikolai Shaughnessy, Michael Daly, Mark J. Artomov, Mykyta Tsao, Hensin JID Innov Original Article Several observational studies have demonstrated a consistent pattern of decreased melanoma risk among patients with vitiligo. More recently, this finding has been supported by a suggested genetic relationship between the two entities, with certain variants significantly associated with an increased risk of melanoma, basal cell carcinoma, and squamous cell carcinoma but a decreased risk of vitiligo. We compared 48 associated variants from a recently published GWAS and identified three variants—located in the TYR, MC1R-DEF8, and RALY-EIF2S2-ASIP-AHCY-ITCH Elsevier 2023-07-08 /pmc/articles/PMC10685305/ /pubmed/38034848 http://dx.doi.org/10.1016/j.xjidi.2023.100217 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Rashid, Sarem
Molotkov, Ivan
Klebanov, Nikolai
Shaughnessy, Michael
Daly, Mark J.
Artomov, Mykyta
Tsao, Hensin
Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo
title Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo
title_full Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo
title_fullStr Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo
title_full_unstemmed Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo
title_short Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo
title_sort mendelian randomization analysis reveals inverse genetic risks between skin cancers and vitiligo
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685305/
https://www.ncbi.nlm.nih.gov/pubmed/38034848
http://dx.doi.org/10.1016/j.xjidi.2023.100217
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