Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC

Obesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR i...

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Detalles Bibliográficos
Autores principales: Kroh, Andreas, Walter, Jeanette, Fragoulis, Athanassios, Möckel, Diana, Lammers, Twan, Kiessling, Fabian, Andruszkow, Julia, Preisinger, Christian, Egbert, Maren, Jiao, Long, Eickhoff, Roman M., Heise, Daniel, Berndt, Nikolaus, Cramer, Thorsten, Neumann, Ulf Peter, Egners, Antje, Ulmer, Tom Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685311/
https://www.ncbi.nlm.nih.gov/pubmed/37976569
http://dx.doi.org/10.1016/j.neo.2023.100945

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