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Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump–hole strategy

Class I inverting exo-acting α-1,2-mannosidases (CAZY family GH47) display an unusual catalytic itinerary featuring ring-flipped mannosides, (3)S(1) → (3)H(4)(‡) → (1)C(4). Conformationally locked (1)C(4) compounds, such as kifunensine, display nanomolar inhibition but large multigene GH47 mannosida...

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Detalles Bibliográficos
Autores principales: Males, Alexandra, Kok, Ken, Nin-Hill, Alba, de Koster, Nicky, van den Beukel, Sija, Beenakker, Thomas J. M., van der Marel, Gijsbert A., Codée, Jeroen D. C., Aerts, Johannes M. F. G., Overkleeft, Herman S., Rovira, Carme, Davies, Gideon J., Artola, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685318/
https://www.ncbi.nlm.nih.gov/pubmed/38033892
http://dx.doi.org/10.1039/d3sc05016e