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Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults

PURPOSE: We explored the interaction of optical coherence tomography (OCT) parameters and white matter hyperintensities with cognitive measures in our older adult cohort. METHODS: This observational study enrolled participants who underwent a comprehensive neuropsychological battery, structural 3-T...

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Autores principales: Wang, Ruilin, Wu, Xinmao, Zhang, Zengyi, Cao, Le, Kwapong, William Robert, Wang, Hang, Tao, Wendan, Ye, Chen, Liu, Junfeng, Wu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685347/
https://www.ncbi.nlm.nih.gov/pubmed/38035269
http://dx.doi.org/10.3389/fnagi.2023.1240815
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author Wang, Ruilin
Wu, Xinmao
Zhang, Zengyi
Cao, Le
Kwapong, William Robert
Wang, Hang
Tao, Wendan
Ye, Chen
Liu, Junfeng
Wu, Bo
author_facet Wang, Ruilin
Wu, Xinmao
Zhang, Zengyi
Cao, Le
Kwapong, William Robert
Wang, Hang
Tao, Wendan
Ye, Chen
Liu, Junfeng
Wu, Bo
author_sort Wang, Ruilin
collection PubMed
description PURPOSE: We explored the interaction of optical coherence tomography (OCT) parameters and white matter hyperintensities with cognitive measures in our older adult cohort. METHODS: This observational study enrolled participants who underwent a comprehensive neuropsychological battery, structural 3-T brain magnetic resonance imaging (MRI), visual acuity examination, and OCT imaging. Cerebral small vessel disease (CSVD) markers were read on MR images; lacune, cerebral microbleeds (CMB), white matter hyperintensities (WMH), and enlarged perivascular spaces (EPVS), were defined according to the STRIVE standards. Retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses (μm) were measured on the OCT tool. RESULTS: Older adults with cognitive impairment (CI) showed lower RNFL (p = 0.001), GCIPL (p = 0.009) thicknesses, and lower hippocampal volume (p = 0.004) when compared to non-cognitively impaired (NCI). RNFL (p = 0.006) and GCIPL thicknesses (p = 0.032) correlated with MoCA scores. GCIPL thickness (p = 0.037), total WMH (p = 0.003), PWMH (p = 0.041), and DWMH (p = 0.001) correlated with hippocampal volume in our older adults after adjusting for covariates. With hippocampal volume as the outcome, a significant interaction (p < 0.05) between GCIPL and PWMH and total WMH was observed in our older adults. CONCLUSION: Both GCIPL thinning and higher WMH burden (especially PWMH) are associated with hippocampal volume and older adults with both pathologies are more susceptible to subclinical cognitive decline.
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spelling pubmed-106853472023-11-30 Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults Wang, Ruilin Wu, Xinmao Zhang, Zengyi Cao, Le Kwapong, William Robert Wang, Hang Tao, Wendan Ye, Chen Liu, Junfeng Wu, Bo Front Aging Neurosci Aging Neuroscience PURPOSE: We explored the interaction of optical coherence tomography (OCT) parameters and white matter hyperintensities with cognitive measures in our older adult cohort. METHODS: This observational study enrolled participants who underwent a comprehensive neuropsychological battery, structural 3-T brain magnetic resonance imaging (MRI), visual acuity examination, and OCT imaging. Cerebral small vessel disease (CSVD) markers were read on MR images; lacune, cerebral microbleeds (CMB), white matter hyperintensities (WMH), and enlarged perivascular spaces (EPVS), were defined according to the STRIVE standards. Retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses (μm) were measured on the OCT tool. RESULTS: Older adults with cognitive impairment (CI) showed lower RNFL (p = 0.001), GCIPL (p = 0.009) thicknesses, and lower hippocampal volume (p = 0.004) when compared to non-cognitively impaired (NCI). RNFL (p = 0.006) and GCIPL thicknesses (p = 0.032) correlated with MoCA scores. GCIPL thickness (p = 0.037), total WMH (p = 0.003), PWMH (p = 0.041), and DWMH (p = 0.001) correlated with hippocampal volume in our older adults after adjusting for covariates. With hippocampal volume as the outcome, a significant interaction (p < 0.05) between GCIPL and PWMH and total WMH was observed in our older adults. CONCLUSION: Both GCIPL thinning and higher WMH burden (especially PWMH) are associated with hippocampal volume and older adults with both pathologies are more susceptible to subclinical cognitive decline. Frontiers Media S.A. 2023-11-15 /pmc/articles/PMC10685347/ /pubmed/38035269 http://dx.doi.org/10.3389/fnagi.2023.1240815 Text en Copyright © 2023 Wang, Wu, Zhang, Cao, Kwapong, Wang, Tao, Ye, Liu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Wang, Ruilin
Wu, Xinmao
Zhang, Zengyi
Cao, Le
Kwapong, William Robert
Wang, Hang
Tao, Wendan
Ye, Chen
Liu, Junfeng
Wu, Bo
Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults
title Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults
title_full Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults
title_fullStr Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults
title_full_unstemmed Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults
title_short Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults
title_sort retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685347/
https://www.ncbi.nlm.nih.gov/pubmed/38035269
http://dx.doi.org/10.3389/fnagi.2023.1240815
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