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Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
It is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685377/ https://www.ncbi.nlm.nih.gov/pubmed/38034818 http://dx.doi.org/10.1016/j.heliyon.2023.e22147 |
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author | Dupont, D. Robert, M.G. Brenier-Pinchart, M.P. Lefevre, A. Wallon, M. Pelloux, H. |
author_facet | Dupont, D. Robert, M.G. Brenier-Pinchart, M.P. Lefevre, A. Wallon, M. Pelloux, H. |
author_sort | Dupont, D. |
collection | PubMed |
description | It is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in animals and humans suggest that this carriage may be linked to various neuropsychiatric or neurodegenerative disorders. The hypothesis of a potential cerebral oncogenicity of the parasite is also emerging. In this personal view, we will present the epidemiological arguments in favour of an association between toxoplasmosis and cerebral malignancy, before considering the points that could underlie a potential causal link. More specifically, we will focus on the brain as the preferred location for T. gondii persistence and the propensity of this parasite to interfere with the apoptosis and cell cycle signalling pathways of their host cell. |
format | Online Article Text |
id | pubmed-10685377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106853772023-11-30 Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential Dupont, D. Robert, M.G. Brenier-Pinchart, M.P. Lefevre, A. Wallon, M. Pelloux, H. Heliyon Review Article It is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in animals and humans suggest that this carriage may be linked to various neuropsychiatric or neurodegenerative disorders. The hypothesis of a potential cerebral oncogenicity of the parasite is also emerging. In this personal view, we will present the epidemiological arguments in favour of an association between toxoplasmosis and cerebral malignancy, before considering the points that could underlie a potential causal link. More specifically, we will focus on the brain as the preferred location for T. gondii persistence and the propensity of this parasite to interfere with the apoptosis and cell cycle signalling pathways of their host cell. Elsevier 2023-11-10 /pmc/articles/PMC10685377/ /pubmed/38034818 http://dx.doi.org/10.1016/j.heliyon.2023.e22147 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Dupont, D. Robert, M.G. Brenier-Pinchart, M.P. Lefevre, A. Wallon, M. Pelloux, H. Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
title | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
title_full | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
title_fullStr | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
title_full_unstemmed | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
title_short | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
title_sort | toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685377/ https://www.ncbi.nlm.nih.gov/pubmed/38034818 http://dx.doi.org/10.1016/j.heliyon.2023.e22147 |
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