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Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential

It is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in...

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Autores principales: Dupont, D., Robert, M.G., Brenier-Pinchart, M.P., Lefevre, A., Wallon, M., Pelloux, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685377/
https://www.ncbi.nlm.nih.gov/pubmed/38034818
http://dx.doi.org/10.1016/j.heliyon.2023.e22147
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author Dupont, D.
Robert, M.G.
Brenier-Pinchart, M.P.
Lefevre, A.
Wallon, M.
Pelloux, H.
author_facet Dupont, D.
Robert, M.G.
Brenier-Pinchart, M.P.
Lefevre, A.
Wallon, M.
Pelloux, H.
author_sort Dupont, D.
collection PubMed
description It is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in animals and humans suggest that this carriage may be linked to various neuropsychiatric or neurodegenerative disorders. The hypothesis of a potential cerebral oncogenicity of the parasite is also emerging. In this personal view, we will present the epidemiological arguments in favour of an association between toxoplasmosis and cerebral malignancy, before considering the points that could underlie a potential causal link. More specifically, we will focus on the brain as the preferred location for T. gondii persistence and the propensity of this parasite to interfere with the apoptosis and cell cycle signalling pathways of their host cell.
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spelling pubmed-106853772023-11-30 Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential Dupont, D. Robert, M.G. Brenier-Pinchart, M.P. Lefevre, A. Wallon, M. Pelloux, H. Heliyon Review Article It is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in animals and humans suggest that this carriage may be linked to various neuropsychiatric or neurodegenerative disorders. The hypothesis of a potential cerebral oncogenicity of the parasite is also emerging. In this personal view, we will present the epidemiological arguments in favour of an association between toxoplasmosis and cerebral malignancy, before considering the points that could underlie a potential causal link. More specifically, we will focus on the brain as the preferred location for T. gondii persistence and the propensity of this parasite to interfere with the apoptosis and cell cycle signalling pathways of their host cell. Elsevier 2023-11-10 /pmc/articles/PMC10685377/ /pubmed/38034818 http://dx.doi.org/10.1016/j.heliyon.2023.e22147 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Dupont, D.
Robert, M.G.
Brenier-Pinchart, M.P.
Lefevre, A.
Wallon, M.
Pelloux, H.
Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
title Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
title_full Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
title_fullStr Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
title_full_unstemmed Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
title_short Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
title_sort toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685377/
https://www.ncbi.nlm.nih.gov/pubmed/38034818
http://dx.doi.org/10.1016/j.heliyon.2023.e22147
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