Exploring the conformational dynamics and thermodynamics of EGFR S768I and G719X + S768I mutations in non-small cell lung cancer: An in silico approaches

Non-small cell lung cancer (NSCLC) is often driven by mutations in the epidermal growth factor receptor (EGFR) gene. However, rare mutations such as G719X and S768I lack standard anti-EGFR targeted therapies. Understanding the structural differences between wild-type EGFR and these rare mutants is c...

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Detalles Bibliográficos
Autores principales: Wang, Jun-Ling, Liu, Ming-Sheng, Fu, Yu-Dong, Kan, Qiang-Bo, Li, Chun-Yan, Ma, Rong, Fang, Zhe-Wei, Liu, Hong-Xia, Li, Meng-Xian, Lv, Jia-Ling, Sang, Peng, Zhang, Chao, Li, Hong-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685407/
https://www.ncbi.nlm.nih.gov/pubmed/38035047
http://dx.doi.org/10.1515/biol-2022-0768

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