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Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children
BACKGROUND: The prevalence of obese children in China is increasing, which poses a great challenge to public health. Gut microbes play an important role in human gut health, and changes in gut status are closely related to obesity. However, how gut microbes contribute to obesity in children remains...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685578/ https://www.ncbi.nlm.nih.gov/pubmed/38031016 http://dx.doi.org/10.1186/s12864-023-09805-4 |
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author | Li, Ping Jiang, Jiyang Li, Yifei Lan, Yue Yang, Fan Wang, Jiao Xie, Yuxin Xiong, Fei Wu, Jinhui Liu, Hanmin Fan, Zhenxin |
author_facet | Li, Ping Jiang, Jiyang Li, Yifei Lan, Yue Yang, Fan Wang, Jiao Xie, Yuxin Xiong, Fei Wu, Jinhui Liu, Hanmin Fan, Zhenxin |
author_sort | Li, Ping |
collection | PubMed |
description | BACKGROUND: The prevalence of obese children in China is increasing, which poses a great challenge to public health. Gut microbes play an important role in human gut health, and changes in gut status are closely related to obesity. However, how gut microbes contribute to obesity in children remains unclear. In our study, we performed shotgun metagenomic sequencing of feces from 23 obese children, 8 overweight children and 22 control children in Chengdu, Sichuan, China. RESULTS: We observed a distinct difference in the gut microbiome of obese children and that of controls. Compared with the controls, bacterial pathogen Campylobacter rectus was significantly more abundant in obese children. In addition, functional annotation of microbial genes revealed that there might be gut inflammation in obese children. The guts of overweight children might belong to the transition state between obese and control children due to a gradient in relative abundance of differentially abundant species. Finally, we compared the gut metagenomes of obese Chinese children and obese Mexican children and found that Trichuris trichiura was significantly more abundant in the guts of obese Mexican children. CONCLUSIONS: Our results contribute to understanding the changes in the species and function of intestinal microbes in obese Chinese children. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12864-023-09805-4. |
format | Online Article Text |
id | pubmed-10685578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106855782023-11-30 Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children Li, Ping Jiang, Jiyang Li, Yifei Lan, Yue Yang, Fan Wang, Jiao Xie, Yuxin Xiong, Fei Wu, Jinhui Liu, Hanmin Fan, Zhenxin BMC Genomics Research BACKGROUND: The prevalence of obese children in China is increasing, which poses a great challenge to public health. Gut microbes play an important role in human gut health, and changes in gut status are closely related to obesity. However, how gut microbes contribute to obesity in children remains unclear. In our study, we performed shotgun metagenomic sequencing of feces from 23 obese children, 8 overweight children and 22 control children in Chengdu, Sichuan, China. RESULTS: We observed a distinct difference in the gut microbiome of obese children and that of controls. Compared with the controls, bacterial pathogen Campylobacter rectus was significantly more abundant in obese children. In addition, functional annotation of microbial genes revealed that there might be gut inflammation in obese children. The guts of overweight children might belong to the transition state between obese and control children due to a gradient in relative abundance of differentially abundant species. Finally, we compared the gut metagenomes of obese Chinese children and obese Mexican children and found that Trichuris trichiura was significantly more abundant in the guts of obese Mexican children. CONCLUSIONS: Our results contribute to understanding the changes in the species and function of intestinal microbes in obese Chinese children. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12864-023-09805-4. BioMed Central 2023-11-29 /pmc/articles/PMC10685578/ /pubmed/38031016 http://dx.doi.org/10.1186/s12864-023-09805-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Li, Ping Jiang, Jiyang Li, Yifei Lan, Yue Yang, Fan Wang, Jiao Xie, Yuxin Xiong, Fei Wu, Jinhui Liu, Hanmin Fan, Zhenxin Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children |
title | Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children |
title_full | Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children |
title_fullStr | Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children |
title_full_unstemmed | Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children |
title_short | Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children |
title_sort | metagenomic analysis reveals distinct changes in the gut microbiome of obese chinese children |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685578/ https://www.ncbi.nlm.nih.gov/pubmed/38031016 http://dx.doi.org/10.1186/s12864-023-09805-4 |
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