Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice

BACKGROUND: Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining the contributi...

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Detalles Bibliográficos
Autores principales: Amor, Melina, Bianco, Valentina, Buerger, Martin, Lechleitner, Margarete, Vujić, Nemanja, Dobrijević, Anja, Akhmetshina, Alena, Pirchheim, Anita, Schwarz, Birgit, Pessentheiner, Ariane R., Baumgartner, Franziska, Rampitsch, Katharina, Schauer, Silvia, Klobučar, Iva, Degoricija, Vesna, Pregartner, Gudrun, Kummer, Daniel, Svecla, Monika, Sommer, Gerhard, Kolb, Dagmar, Holzapfel, Gerhard A., Hoefler, Gerald, Frank, Saša, Norata, Giuseppe Danilo, Kratky, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685620/
https://www.ncbi.nlm.nih.gov/pubmed/38017481
http://dx.doi.org/10.1186/s12933-023-02064-3

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