Natural killer cells in the central nervous system

Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators. Accumulating evidence points to interactions between NK cells and the central nervous system (CNS). Here, we review the basic knowledge of NK cell biolog...

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Detalles Bibliográficos
Autores principales: Ning, Zhiyuan, Liu, Ying, Guo, Daji, Lin, Wei-Jye, Tang, Yamei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685650/
https://www.ncbi.nlm.nih.gov/pubmed/38031097
http://dx.doi.org/10.1186/s12964-023-01324-9
Descripción
Sumario:Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators. Accumulating evidence points to interactions between NK cells and the central nervous system (CNS). Here, we review the basic knowledge of NK cell biology and recent advances in their roles in the healthy CNS and pathological conditions, with a focus on normal aging, CNS autoimmune diseases, neurodegenerative diseases, cerebrovascular diseases, and CNS infections. We highlight the crosstalk between NK cells and diverse cell types in the CNS and the potential value of NK cells as novel therapeutic targets for CNS diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01324-9.

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