Natural killer cells in the central nervous system

Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators. Accumulating evidence points to interactions between NK cells and the central nervous system (CNS). Here, we review the basic knowledge of NK cell biolog...

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Autores principales: Ning, Zhiyuan, Liu, Ying, Guo, Daji, Lin, Wei-Jye, Tang, Yamei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685650/
https://www.ncbi.nlm.nih.gov/pubmed/38031097
http://dx.doi.org/10.1186/s12964-023-01324-9
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author Ning, Zhiyuan
Liu, Ying
Guo, Daji
Lin, Wei-Jye
Tang, Yamei
author_facet Ning, Zhiyuan
Liu, Ying
Guo, Daji
Lin, Wei-Jye
Tang, Yamei
author_sort Ning, Zhiyuan
collection PubMed
description Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators. Accumulating evidence points to interactions between NK cells and the central nervous system (CNS). Here, we review the basic knowledge of NK cell biology and recent advances in their roles in the healthy CNS and pathological conditions, with a focus on normal aging, CNS autoimmune diseases, neurodegenerative diseases, cerebrovascular diseases, and CNS infections. We highlight the crosstalk between NK cells and diverse cell types in the CNS and the potential value of NK cells as novel therapeutic targets for CNS diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01324-9.
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spelling pubmed-106856502023-11-30 Natural killer cells in the central nervous system Ning, Zhiyuan Liu, Ying Guo, Daji Lin, Wei-Jye Tang, Yamei Cell Commun Signal Review Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators. Accumulating evidence points to interactions between NK cells and the central nervous system (CNS). Here, we review the basic knowledge of NK cell biology and recent advances in their roles in the healthy CNS and pathological conditions, with a focus on normal aging, CNS autoimmune diseases, neurodegenerative diseases, cerebrovascular diseases, and CNS infections. We highlight the crosstalk between NK cells and diverse cell types in the CNS and the potential value of NK cells as novel therapeutic targets for CNS diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01324-9. BioMed Central 2023-11-29 /pmc/articles/PMC10685650/ /pubmed/38031097 http://dx.doi.org/10.1186/s12964-023-01324-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ning, Zhiyuan
Liu, Ying
Guo, Daji
Lin, Wei-Jye
Tang, Yamei
Natural killer cells in the central nervous system
title Natural killer cells in the central nervous system
title_full Natural killer cells in the central nervous system
title_fullStr Natural killer cells in the central nervous system
title_full_unstemmed Natural killer cells in the central nervous system
title_short Natural killer cells in the central nervous system
title_sort natural killer cells in the central nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685650/
https://www.ncbi.nlm.nih.gov/pubmed/38031097
http://dx.doi.org/10.1186/s12964-023-01324-9
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