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SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1

BACKGROUND: Endothelial–mesenchymal transition (EndMT) plays a crucial role in promoting myocardial fibrosis and exacerbating cardiac dysfunction. Dapagliflozin (DAPA) is a sodium–glucose-linked transporter 2 (SGLT-2) inhibitor that has been shown to improve cardiac function in non-diabetic patients...

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Detalles Bibliográficos
Autores principales:	Wang, Weijie, Li, Yilan, Zhang, Yanxiu, Ye, Tao, Wang, Kui, Li, Shuijie, Zhang, Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685714/ https://www.ncbi.nlm.nih.gov/pubmed/38017499 http://dx.doi.org/10.1186/s12933-023-02040-x

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