Small molecule modulators of immune pattern recognition receptors

Pattern recognition receptors (PRRs) represent a re-emerging class of therapeutic targets for vaccine adjuvants, inflammatory diseases and cancer. In this review article, we summarize exciting developments in discovery and characterization of small molecule PRR modulators, focusing on Toll-like rece...

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Detalles Bibliográficos
Autores principales: Tsukidate, Taku, Hespen, Charles W., Hang, Howard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685800/
https://www.ncbi.nlm.nih.gov/pubmed/38033733
http://dx.doi.org/10.1039/d3cb00096f
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author Tsukidate, Taku
Hespen, Charles W.
Hang, Howard C.
author_facet Tsukidate, Taku
Hespen, Charles W.
Hang, Howard C.
author_sort Tsukidate, Taku
collection PubMed
description Pattern recognition receptors (PRRs) represent a re-emerging class of therapeutic targets for vaccine adjuvants, inflammatory diseases and cancer. In this review article, we summarize exciting developments in discovery and characterization of small molecule PRR modulators, focusing on Toll-like receptors (TLRs), NOD-like receptors (NLRs) and the cGAS-STING pathway. We also highlight PRRs that are currently lacking small molecule modulators and opportunities for chemical biology and therapeutic discovery.
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spelling pubmed-106858002023-11-30 Small molecule modulators of immune pattern recognition receptors Tsukidate, Taku Hespen, Charles W. Hang, Howard C. RSC Chem Biol Chemistry Pattern recognition receptors (PRRs) represent a re-emerging class of therapeutic targets for vaccine adjuvants, inflammatory diseases and cancer. In this review article, we summarize exciting developments in discovery and characterization of small molecule PRR modulators, focusing on Toll-like receptors (TLRs), NOD-like receptors (NLRs) and the cGAS-STING pathway. We also highlight PRRs that are currently lacking small molecule modulators and opportunities for chemical biology and therapeutic discovery. RSC 2023-10-23 /pmc/articles/PMC10685800/ /pubmed/38033733 http://dx.doi.org/10.1039/d3cb00096f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tsukidate, Taku
Hespen, Charles W.
Hang, Howard C.
Small molecule modulators of immune pattern recognition receptors
title Small molecule modulators of immune pattern recognition receptors
title_full Small molecule modulators of immune pattern recognition receptors
title_fullStr Small molecule modulators of immune pattern recognition receptors
title_full_unstemmed Small molecule modulators of immune pattern recognition receptors
title_short Small molecule modulators of immune pattern recognition receptors
title_sort small molecule modulators of immune pattern recognition receptors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685800/
https://www.ncbi.nlm.nih.gov/pubmed/38033733
http://dx.doi.org/10.1039/d3cb00096f
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