Cargando…

Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study

OBJECTIVE: To determine and compare the mean maternal serum leptin levels, the prevalence of high serum leptin levels and mean gestational weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria. METHODS: This cross-sectional comparative study enrolled obese and non-obese preg...

Descripción completa

Detalles Bibliográficos
Autores principales: Enebe, Joseph Tochukwu, Enebe, Nympha Onyinye, Nwagha, Theresa Ukamaka, Meka, Ijeoma Angela, Nwankwo, Malackay Ezenwaeze, Izuka, Emmanuel Obiora, Egede, John Okafor, Ugwu, Innocent Anayochukwu, Okoro, Ngozi Ijeoma, Okoye, Helen Chioma, Iyoke, Chukwuemeka Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686020/
https://www.ncbi.nlm.nih.gov/pubmed/38017364
http://dx.doi.org/10.1177/03000605231213265
_version_ 1785151734158458880
author Enebe, Joseph Tochukwu
Enebe, Nympha Onyinye
Nwagha, Theresa Ukamaka
Meka, Ijeoma Angela
Nwankwo, Malackay Ezenwaeze
Izuka, Emmanuel Obiora
Egede, John Okafor
Ugwu, Innocent Anayochukwu
Okoro, Ngozi Ijeoma
Okoye, Helen Chioma
Iyoke, Chukwuemeka Anthony
author_facet Enebe, Joseph Tochukwu
Enebe, Nympha Onyinye
Nwagha, Theresa Ukamaka
Meka, Ijeoma Angela
Nwankwo, Malackay Ezenwaeze
Izuka, Emmanuel Obiora
Egede, John Okafor
Ugwu, Innocent Anayochukwu
Okoro, Ngozi Ijeoma
Okoye, Helen Chioma
Iyoke, Chukwuemeka Anthony
author_sort Enebe, Joseph Tochukwu
collection PubMed
description OBJECTIVE: To determine and compare the mean maternal serum leptin levels, the prevalence of high serum leptin levels and mean gestational weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria. METHODS: This cross-sectional comparative study enrolled obese and non-obese pregnant women. The serum leptin levels of the women were determined using an enzyme-linked immunosorbent assay kit. Anthropometric and sociodemographic data were obtained and compared. Mean weight gain during pregnancy was determined. RESULTS: A total of 170 pregnant women were included in the study. The mean ± SD serum leptin level (99.39 ± 50.2 ng/ml) and the prevalence of hyperleptinaemia (81 of 85 patients; 95.3%) among the obese pregnant women at term were significantly higher than those of the non-obese pregnant women (48.98 ± 30.35 ng/ml/65 of 85 patients; 76.5%). The mean percentage weight gain was significantly higher in the non-obese women compared with the obese women at term. The predictors of high maternal serum leptin level at term among the participants were the employment status and levels of education of the participants. CONCLUSION: Maternal serum leptin level, maternal weight gain and prevalence of hyperleptinaemia at term were significantly higher in the obese compared with the non-obese pregnant women.
format Online
Article
Text
id pubmed-10686020
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-106860202023-11-30 Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study Enebe, Joseph Tochukwu Enebe, Nympha Onyinye Nwagha, Theresa Ukamaka Meka, Ijeoma Angela Nwankwo, Malackay Ezenwaeze Izuka, Emmanuel Obiora Egede, John Okafor Ugwu, Innocent Anayochukwu Okoro, Ngozi Ijeoma Okoye, Helen Chioma Iyoke, Chukwuemeka Anthony J Int Med Res Prospective Clinical Research Report OBJECTIVE: To determine and compare the mean maternal serum leptin levels, the prevalence of high serum leptin levels and mean gestational weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria. METHODS: This cross-sectional comparative study enrolled obese and non-obese pregnant women. The serum leptin levels of the women were determined using an enzyme-linked immunosorbent assay kit. Anthropometric and sociodemographic data were obtained and compared. Mean weight gain during pregnancy was determined. RESULTS: A total of 170 pregnant women were included in the study. The mean ± SD serum leptin level (99.39 ± 50.2 ng/ml) and the prevalence of hyperleptinaemia (81 of 85 patients; 95.3%) among the obese pregnant women at term were significantly higher than those of the non-obese pregnant women (48.98 ± 30.35 ng/ml/65 of 85 patients; 76.5%). The mean percentage weight gain was significantly higher in the non-obese women compared with the obese women at term. The predictors of high maternal serum leptin level at term among the participants were the employment status and levels of education of the participants. CONCLUSION: Maternal serum leptin level, maternal weight gain and prevalence of hyperleptinaemia at term were significantly higher in the obese compared with the non-obese pregnant women. SAGE Publications 2023-11-28 /pmc/articles/PMC10686020/ /pubmed/38017364 http://dx.doi.org/10.1177/03000605231213265 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospective Clinical Research Report
Enebe, Joseph Tochukwu
Enebe, Nympha Onyinye
Nwagha, Theresa Ukamaka
Meka, Ijeoma Angela
Nwankwo, Malackay Ezenwaeze
Izuka, Emmanuel Obiora
Egede, John Okafor
Ugwu, Innocent Anayochukwu
Okoro, Ngozi Ijeoma
Okoye, Helen Chioma
Iyoke, Chukwuemeka Anthony
Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study
title Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study
title_full Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study
title_fullStr Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study
title_full_unstemmed Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study
title_short Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study
title_sort serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in enugu, nigeria: a comparative cross-sectional study
topic Prospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686020/
https://www.ncbi.nlm.nih.gov/pubmed/38017364
http://dx.doi.org/10.1177/03000605231213265
work_keys_str_mv AT enebejosephtochukwu serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT enebenymphaonyinye serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT nwaghatheresaukamaka serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT mekaijeomaangela serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT nwankwomalackayezenwaeze serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT izukaemmanuelobiora serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT egedejohnokafor serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT ugwuinnocentanayochukwu serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT okorongoziijeoma serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT okoyehelenchioma serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy
AT iyokechukwuemekaanthony serumleptinlevelsandrelationshipwithmaternalweightgainattermamongobeseandnonobesepregnantwomeninenugunigeriaacomparativecrosssectionalstudy