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Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study
OBJECTIVE: To determine and compare the mean maternal serum leptin levels, the prevalence of high serum leptin levels and mean gestational weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria. METHODS: This cross-sectional comparative study enrolled obese and non-obese preg...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686020/ https://www.ncbi.nlm.nih.gov/pubmed/38017364 http://dx.doi.org/10.1177/03000605231213265 |
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author | Enebe, Joseph Tochukwu Enebe, Nympha Onyinye Nwagha, Theresa Ukamaka Meka, Ijeoma Angela Nwankwo, Malackay Ezenwaeze Izuka, Emmanuel Obiora Egede, John Okafor Ugwu, Innocent Anayochukwu Okoro, Ngozi Ijeoma Okoye, Helen Chioma Iyoke, Chukwuemeka Anthony |
author_facet | Enebe, Joseph Tochukwu Enebe, Nympha Onyinye Nwagha, Theresa Ukamaka Meka, Ijeoma Angela Nwankwo, Malackay Ezenwaeze Izuka, Emmanuel Obiora Egede, John Okafor Ugwu, Innocent Anayochukwu Okoro, Ngozi Ijeoma Okoye, Helen Chioma Iyoke, Chukwuemeka Anthony |
author_sort | Enebe, Joseph Tochukwu |
collection | PubMed |
description | OBJECTIVE: To determine and compare the mean maternal serum leptin levels, the prevalence of high serum leptin levels and mean gestational weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria. METHODS: This cross-sectional comparative study enrolled obese and non-obese pregnant women. The serum leptin levels of the women were determined using an enzyme-linked immunosorbent assay kit. Anthropometric and sociodemographic data were obtained and compared. Mean weight gain during pregnancy was determined. RESULTS: A total of 170 pregnant women were included in the study. The mean ± SD serum leptin level (99.39 ± 50.2 ng/ml) and the prevalence of hyperleptinaemia (81 of 85 patients; 95.3%) among the obese pregnant women at term were significantly higher than those of the non-obese pregnant women (48.98 ± 30.35 ng/ml/65 of 85 patients; 76.5%). The mean percentage weight gain was significantly higher in the non-obese women compared with the obese women at term. The predictors of high maternal serum leptin level at term among the participants were the employment status and levels of education of the participants. CONCLUSION: Maternal serum leptin level, maternal weight gain and prevalence of hyperleptinaemia at term were significantly higher in the obese compared with the non-obese pregnant women. |
format | Online Article Text |
id | pubmed-10686020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-106860202023-11-30 Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study Enebe, Joseph Tochukwu Enebe, Nympha Onyinye Nwagha, Theresa Ukamaka Meka, Ijeoma Angela Nwankwo, Malackay Ezenwaeze Izuka, Emmanuel Obiora Egede, John Okafor Ugwu, Innocent Anayochukwu Okoro, Ngozi Ijeoma Okoye, Helen Chioma Iyoke, Chukwuemeka Anthony J Int Med Res Prospective Clinical Research Report OBJECTIVE: To determine and compare the mean maternal serum leptin levels, the prevalence of high serum leptin levels and mean gestational weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria. METHODS: This cross-sectional comparative study enrolled obese and non-obese pregnant women. The serum leptin levels of the women were determined using an enzyme-linked immunosorbent assay kit. Anthropometric and sociodemographic data were obtained and compared. Mean weight gain during pregnancy was determined. RESULTS: A total of 170 pregnant women were included in the study. The mean ± SD serum leptin level (99.39 ± 50.2 ng/ml) and the prevalence of hyperleptinaemia (81 of 85 patients; 95.3%) among the obese pregnant women at term were significantly higher than those of the non-obese pregnant women (48.98 ± 30.35 ng/ml/65 of 85 patients; 76.5%). The mean percentage weight gain was significantly higher in the non-obese women compared with the obese women at term. The predictors of high maternal serum leptin level at term among the participants were the employment status and levels of education of the participants. CONCLUSION: Maternal serum leptin level, maternal weight gain and prevalence of hyperleptinaemia at term were significantly higher in the obese compared with the non-obese pregnant women. SAGE Publications 2023-11-28 /pmc/articles/PMC10686020/ /pubmed/38017364 http://dx.doi.org/10.1177/03000605231213265 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Prospective Clinical Research Report Enebe, Joseph Tochukwu Enebe, Nympha Onyinye Nwagha, Theresa Ukamaka Meka, Ijeoma Angela Nwankwo, Malackay Ezenwaeze Izuka, Emmanuel Obiora Egede, John Okafor Ugwu, Innocent Anayochukwu Okoro, Ngozi Ijeoma Okoye, Helen Chioma Iyoke, Chukwuemeka Anthony Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study |
title | Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study |
title_full | Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study |
title_fullStr | Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study |
title_full_unstemmed | Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study |
title_short | Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study |
title_sort | serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in enugu, nigeria: a comparative cross-sectional study |
topic | Prospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686020/ https://www.ncbi.nlm.nih.gov/pubmed/38017364 http://dx.doi.org/10.1177/03000605231213265 |
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