Rapid discovery of terpene tailoring enzymes for total biosynthesis

Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal a...

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Autores principales: Sun, Yunlong, Gerke, Jennifer, Becker, Kevin, Kuhnert, Eric, Verwaaijen, Bart, Wibberg, Daniel, Kalinowski, Jörn, Stadler, Marc, Cox, Russell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686045/
https://www.ncbi.nlm.nih.gov/pubmed/38033887
http://dx.doi.org/10.1039/d3sc04172g
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author Sun, Yunlong
Gerke, Jennifer
Becker, Kevin
Kuhnert, Eric
Verwaaijen, Bart
Wibberg, Daniel
Kalinowski, Jörn
Stadler, Marc
Cox, Russell J.
author_facet Sun, Yunlong
Gerke, Jennifer
Becker, Kevin
Kuhnert, Eric
Verwaaijen, Bart
Wibberg, Daniel
Kalinowski, Jörn
Stadler, Marc
Cox, Russell J.
author_sort Sun, Yunlong
collection PubMed
description Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal aromatase was discovered that produces phenols by oxidative demethylation.
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spelling pubmed-106860452023-11-30 Rapid discovery of terpene tailoring enzymes for total biosynthesis Sun, Yunlong Gerke, Jennifer Becker, Kevin Kuhnert, Eric Verwaaijen, Bart Wibberg, Daniel Kalinowski, Jörn Stadler, Marc Cox, Russell J. Chem Sci Chemistry Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal aromatase was discovered that produces phenols by oxidative demethylation. The Royal Society of Chemistry 2023-11-08 /pmc/articles/PMC10686045/ /pubmed/38033887 http://dx.doi.org/10.1039/d3sc04172g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Sun, Yunlong
Gerke, Jennifer
Becker, Kevin
Kuhnert, Eric
Verwaaijen, Bart
Wibberg, Daniel
Kalinowski, Jörn
Stadler, Marc
Cox, Russell J.
Rapid discovery of terpene tailoring enzymes for total biosynthesis
title Rapid discovery of terpene tailoring enzymes for total biosynthesis
title_full Rapid discovery of terpene tailoring enzymes for total biosynthesis
title_fullStr Rapid discovery of terpene tailoring enzymes for total biosynthesis
title_full_unstemmed Rapid discovery of terpene tailoring enzymes for total biosynthesis
title_short Rapid discovery of terpene tailoring enzymes for total biosynthesis
title_sort rapid discovery of terpene tailoring enzymes for total biosynthesis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686045/
https://www.ncbi.nlm.nih.gov/pubmed/38033887
http://dx.doi.org/10.1039/d3sc04172g
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