Strategies for the production of isotopically labelled Fab fragments of therapeutic antibodies in Komagataella phaffii (Pichia pastoris) and Escherichia coli for NMR studies

The importance and fast growth of therapeutic monoclonal antibodies, both innovator and biosimilar products, have triggered the need for the development of characterization methods at high resolution such as nuclear magnetic resonance (NMR) spectroscopy. However, the full power of NMR spectroscopy c...

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Detalles Bibliográficos
Autores principales: Gagné, Donald, Sarker, Muzaddid, Gingras, Geneviève, Hodgson, Derek J., Frahm, Grant, Creskey, Marybeth, Lorbetskie, Barry, Bigelow, Stewart, Wang, Jun, Zhang, Xu, Johnston, Michael J. W., Lu, Huixin, Aubin, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686436/
https://www.ncbi.nlm.nih.gov/pubmed/38019850
http://dx.doi.org/10.1371/journal.pone.0294406

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