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Predictors of multidrug-resistant tuberculosis in a teaching hospital in Ghana: A case-control study

Multidrug-resistant Tuberculosis (MDR-TB) remains a global health concern. The disease results in a prolonged treatment and hence, poses a financial burden to affected individuals and their families. The Ghana National TB Control Programme (NTP) has made extensive efforts to control the menace, howe...

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Autores principales: Afful, Philomina, Vechey, Godwin Adjei, Leta, Peter Kipo, Gbafu, Foster Bediako, Aku, Fortress Yayra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686500/
https://www.ncbi.nlm.nih.gov/pubmed/38019801
http://dx.doi.org/10.1371/journal.pone.0294928
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author Afful, Philomina
Vechey, Godwin Adjei
Leta, Peter Kipo
Gbafu, Foster Bediako
Aku, Fortress Yayra
author_facet Afful, Philomina
Vechey, Godwin Adjei
Leta, Peter Kipo
Gbafu, Foster Bediako
Aku, Fortress Yayra
author_sort Afful, Philomina
collection PubMed
description Multidrug-resistant Tuberculosis (MDR-TB) remains a global health concern. The disease results in a prolonged treatment and hence, poses a financial burden to affected individuals and their families. The Ghana National TB Control Programme (NTP) has made extensive efforts to control the menace, however, it remains a concern. This study, therefore, aimed to determine the predictors of multidrug-resistant TB in the Cape Coast Teaching Hospital of Ghana. An unmatched case-control study involving 37 cases and 111 controls was conducted using data of TB cases registered for treatment between January 2018 and December 2020 at the Cape Coast Teaching Hospital. Socio-demographic, individual level and social characteristics information were collected from respondents through telephone surveys, face-to-face interviews and review of records using a structured questionnaire built in the Kobo Collect Toolbox. The data was exported to Stata version 16.0 for analysis. Chi-square test and multiple logistic regression were used to determine the predictors of MDR-TB. Associations were considered statistically significant at a 95% confidence interval with a p-value of less than 0.05. The results revealed that the majority (25 [67.6%]) of MDR-TB cases and controls (76 [68.5%]) were aged 30 years and above with a median age of 36.5 (IQR: 28–50) years for all respondents, while 20 (54.1%) of MDR-TB cases and 33 (29.7%) of controls lived in households with one room residences for their families. The following predictors for MDR-TB were identified: BCG vaccination status (AOR = 0.17,95% CI:0.07–0.45), long distance to health facility (AOR = 4.11, 95% CI: 1.55–10.87), number of rooms in residence (AOR = 0.37,95% CI: 0.14–0.99) and first place of visit upon noticing TB symptom (AOR = 4.22,95% CI:1.31–13.64). Predictors of MDR-TB in the current study were multi-faceted. Measures to control MDR-TB should target socio-demographic, health-seeking behaviour and social-related concerns.
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spelling pubmed-106865002023-11-30 Predictors of multidrug-resistant tuberculosis in a teaching hospital in Ghana: A case-control study Afful, Philomina Vechey, Godwin Adjei Leta, Peter Kipo Gbafu, Foster Bediako Aku, Fortress Yayra PLoS One Research Article Multidrug-resistant Tuberculosis (MDR-TB) remains a global health concern. The disease results in a prolonged treatment and hence, poses a financial burden to affected individuals and their families. The Ghana National TB Control Programme (NTP) has made extensive efforts to control the menace, however, it remains a concern. This study, therefore, aimed to determine the predictors of multidrug-resistant TB in the Cape Coast Teaching Hospital of Ghana. An unmatched case-control study involving 37 cases and 111 controls was conducted using data of TB cases registered for treatment between January 2018 and December 2020 at the Cape Coast Teaching Hospital. Socio-demographic, individual level and social characteristics information were collected from respondents through telephone surveys, face-to-face interviews and review of records using a structured questionnaire built in the Kobo Collect Toolbox. The data was exported to Stata version 16.0 for analysis. Chi-square test and multiple logistic regression were used to determine the predictors of MDR-TB. Associations were considered statistically significant at a 95% confidence interval with a p-value of less than 0.05. The results revealed that the majority (25 [67.6%]) of MDR-TB cases and controls (76 [68.5%]) were aged 30 years and above with a median age of 36.5 (IQR: 28–50) years for all respondents, while 20 (54.1%) of MDR-TB cases and 33 (29.7%) of controls lived in households with one room residences for their families. The following predictors for MDR-TB were identified: BCG vaccination status (AOR = 0.17,95% CI:0.07–0.45), long distance to health facility (AOR = 4.11, 95% CI: 1.55–10.87), number of rooms in residence (AOR = 0.37,95% CI: 0.14–0.99) and first place of visit upon noticing TB symptom (AOR = 4.22,95% CI:1.31–13.64). Predictors of MDR-TB in the current study were multi-faceted. Measures to control MDR-TB should target socio-demographic, health-seeking behaviour and social-related concerns. Public Library of Science 2023-11-29 /pmc/articles/PMC10686500/ /pubmed/38019801 http://dx.doi.org/10.1371/journal.pone.0294928 Text en © 2023 Afful et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Afful, Philomina
Vechey, Godwin Adjei
Leta, Peter Kipo
Gbafu, Foster Bediako
Aku, Fortress Yayra
Predictors of multidrug-resistant tuberculosis in a teaching hospital in Ghana: A case-control study
title Predictors of multidrug-resistant tuberculosis in a teaching hospital in Ghana: A case-control study
title_full Predictors of multidrug-resistant tuberculosis in a teaching hospital in Ghana: A case-control study
title_fullStr Predictors of multidrug-resistant tuberculosis in a teaching hospital in Ghana: A case-control study
title_full_unstemmed Predictors of multidrug-resistant tuberculosis in a teaching hospital in Ghana: A case-control study
title_short Predictors of multidrug-resistant tuberculosis in a teaching hospital in Ghana: A case-control study
title_sort predictors of multidrug-resistant tuberculosis in a teaching hospital in ghana: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686500/
https://www.ncbi.nlm.nih.gov/pubmed/38019801
http://dx.doi.org/10.1371/journal.pone.0294928
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