Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts

Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless, the impact of TF dynamics on reprogramming efficiency remains uncharted. We develop a system that acc...

Descripción completa

Detalles Bibliográficos
Autores principales: Ilia, Katherine, Shakiba, Nika, Bingham, Trevor, Jones, Ross D., Kaminski, Michael M., Aravera, Eliezer, Bruno, Simone, Palacios, Sebastian, Weiss, Ron, Collins, James J., Del Vecchio, Domitilla, Schlaeger, Thorsten M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686568/
https://www.ncbi.nlm.nih.gov/pubmed/38019912
http://dx.doi.org/10.1126/sciadv.adg8495

Ejemplares similares

Ejemplares similares