The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma: Noncoding RNAs in the tumor microenvironment of HCC

Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells. Hypoxia is an important component of the TME, and hypoxia-inducible factor-1α (HIF-1α) is the most importan...

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Autores principales: Yang, Qianqian, Tian, Hui, Guo, Ziyi, Ma, Zhongliang, Wang, Guangzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686793/
https://www.ncbi.nlm.nih.gov/pubmed/37867435
http://dx.doi.org/10.3724/abbs.2023231
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author Yang, Qianqian
Tian, Hui
Guo, Ziyi
Ma, Zhongliang
Wang, Guangzhi
author_facet Yang, Qianqian
Tian, Hui
Guo, Ziyi
Ma, Zhongliang
Wang, Guangzhi
author_sort Yang, Qianqian
collection PubMed
description Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells. Hypoxia is an important component of the TME, and hypoxia-inducible factor-1α (HIF-1α) is the most important transcriptional regulator. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), comprise a large part of the human transcriptome and play an important role in regulating the tumorigenesis of HCC. This review discusses the role of ncRNAs in hepatocarcinogenesis, epithelial-mesenchymal transition (EMT), and angiogenesis in a hypoxic microenvironment, as well as the interactions between ncRNAs and key components of the TME. It further discusses their use as biomarkers and the potential clinical value of drugs, as well as the challenges faced in the future.
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spelling pubmed-106867932023-11-30 The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma: Noncoding RNAs in the tumor microenvironment of HCC Yang, Qianqian Tian, Hui Guo, Ziyi Ma, Zhongliang Wang, Guangzhi Acta Biochim Biophys Sin (Shanghai) Research Article Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells. Hypoxia is an important component of the TME, and hypoxia-inducible factor-1α (HIF-1α) is the most important transcriptional regulator. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), comprise a large part of the human transcriptome and play an important role in regulating the tumorigenesis of HCC. This review discusses the role of ncRNAs in hepatocarcinogenesis, epithelial-mesenchymal transition (EMT), and angiogenesis in a hypoxic microenvironment, as well as the interactions between ncRNAs and key components of the TME. It further discusses their use as biomarkers and the potential clinical value of drugs, as well as the challenges faced in the future. Oxford University Press 2023-10-23 /pmc/articles/PMC10686793/ /pubmed/37867435 http://dx.doi.org/10.3724/abbs.2023231 Text en © The Author(s) 2021. 0 https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Research Article
Yang, Qianqian
Tian, Hui
Guo, Ziyi
Ma, Zhongliang
Wang, Guangzhi
The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma: Noncoding RNAs in the tumor microenvironment of HCC
title The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma: Noncoding RNAs in the tumor microenvironment of HCC
title_full The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma: Noncoding RNAs in the tumor microenvironment of HCC
title_fullStr The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma: Noncoding RNAs in the tumor microenvironment of HCC
title_full_unstemmed The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma: Noncoding RNAs in the tumor microenvironment of HCC
title_short The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma: Noncoding RNAs in the tumor microenvironment of HCC
title_sort role of noncoding rnas in the tumor microenvironment of hepatocellular carcinoma: noncoding rnas in the tumor microenvironment of hcc
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686793/
https://www.ncbi.nlm.nih.gov/pubmed/37867435
http://dx.doi.org/10.3724/abbs.2023231
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