HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis

Melanomas can adopt multiple transcriptional states. Little is known about the epigenetic drivers of these cell states, limiting our ability to regulate melanoma heterogeneity. Here, we identify stress-induced HDAC8 activity as driving melanoma brain metastasis development. Exposure of melanocytes a...

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Detalles Bibliográficos
Autores principales: Emmons, Michael F., Bennett, Richard L., Riva, Alberto, Gupta, Kanchan, Carvalho, Larissa Anastasio Da Costa, Zhang, Chao, Macaulay, Robert, Dupéré-Richér, Daphne, Fang, Bin, Seto, Edward, Koomen, John M., Li, Jiannong, Chen, Y. Ann, Forsyth, Peter A., Licht, Jonathan D., Smalley, Keiran S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686983/
https://www.ncbi.nlm.nih.gov/pubmed/38030596
http://dx.doi.org/10.1038/s41467-023-43519-1

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