Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization

Macrophage polarization plays an important role in asthma. Nuclear receptor corepressor 1 (NCOR1) plays an important role in metabolic and cardiovascular diseases by regulating the function of macrophages. The aim of this research was to examine the role and mechanism of macrophage NCOR1 in the deve...

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Autores principales: Hou, Chenchen, Yan, Lifeng, Sun, Ke, Zhou, Tianyu, Zou, Yuxin, Xiong, Weining, Duan, Sheng-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687133/
https://www.ncbi.nlm.nih.gov/pubmed/38030614
http://dx.doi.org/10.1038/s41420-023-01724-3
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author Hou, Chenchen
Yan, Lifeng
Sun, Ke
Zhou, Tianyu
Zou, Yuxin
Xiong, Weining
Duan, Sheng-Zhong
author_facet Hou, Chenchen
Yan, Lifeng
Sun, Ke
Zhou, Tianyu
Zou, Yuxin
Xiong, Weining
Duan, Sheng-Zhong
author_sort Hou, Chenchen
collection PubMed
description Macrophage polarization plays an important role in asthma. Nuclear receptor corepressor 1 (NCOR1) plays an important role in metabolic and cardiovascular diseases by regulating the function of macrophages. The aim of this research was to examine the role and mechanism of macrophage NCOR1 in the development of asthma. We used ovalbumin (OVA) to induce macrophage NCOR1-deficient mice for asthma formation. Our results revealed that macrophage NCOR1 deficiency markedly enhanced allergic airway inflammation. In addition, NCOR1 deficiency in macrophages was found to enhance M2 polarization. Mechanistic studies suggested that NCOR1 promoted macrophage polarization by interacting with PPARγ, contributing to the pathogenesis of asthma. In conclusion, macrophage NCOR1 deficiency promoted the regulation of M2 programming by enhancing PPARγ expression to exacerbate asthma. Macrophage NCOR1 might be a potential target for the treatment of asthma.
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spelling pubmed-106871332023-11-30 Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization Hou, Chenchen Yan, Lifeng Sun, Ke Zhou, Tianyu Zou, Yuxin Xiong, Weining Duan, Sheng-Zhong Cell Death Discov Article Macrophage polarization plays an important role in asthma. Nuclear receptor corepressor 1 (NCOR1) plays an important role in metabolic and cardiovascular diseases by regulating the function of macrophages. The aim of this research was to examine the role and mechanism of macrophage NCOR1 in the development of asthma. We used ovalbumin (OVA) to induce macrophage NCOR1-deficient mice for asthma formation. Our results revealed that macrophage NCOR1 deficiency markedly enhanced allergic airway inflammation. In addition, NCOR1 deficiency in macrophages was found to enhance M2 polarization. Mechanistic studies suggested that NCOR1 promoted macrophage polarization by interacting with PPARγ, contributing to the pathogenesis of asthma. In conclusion, macrophage NCOR1 deficiency promoted the regulation of M2 programming by enhancing PPARγ expression to exacerbate asthma. Macrophage NCOR1 might be a potential target for the treatment of asthma. Nature Publishing Group UK 2023-11-29 /pmc/articles/PMC10687133/ /pubmed/38030614 http://dx.doi.org/10.1038/s41420-023-01724-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hou, Chenchen
Yan, Lifeng
Sun, Ke
Zhou, Tianyu
Zou, Yuxin
Xiong, Weining
Duan, Sheng-Zhong
Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization
title Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization
title_full Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization
title_fullStr Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization
title_full_unstemmed Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization
title_short Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization
title_sort nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687133/
https://www.ncbi.nlm.nih.gov/pubmed/38030614
http://dx.doi.org/10.1038/s41420-023-01724-3
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