Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m(5)C at GCU motifs

RNA modifications, such as methylation, can be detected with Oxford Nanopore Technologies direct RNA sequencing. One commonly used tool for detecting 5-methylcytosine (m(5)C) modifications is Tombo, which uses an “Alternative Model” to detect putative modifications from a single sample. We examined...

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Detalles Bibliográficos
Autores principales: Watson, Kaylee J, Bromley, Robin E, Sparklin, Benjamin C, Gasser, Mark T, Bhattacharya, Tamanash, Lebov, Jarrett F, Tyson, Tyonna, Dai, Nan, Teigen, Laura E, Graf, Karen T, Foster, Jeremy M, Michalski, Michelle, Bruno, Vincent M, Lindsey, Amelia RI, Corrêa, Ivan R, Hardy, Richard W, Newton, Irene LG, Dunning Hotopp, Julie C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687253/
https://www.ncbi.nlm.nih.gov/pubmed/38030223
http://dx.doi.org/10.26508/lsa.202302201

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