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Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study
Introduction: Approximately 5.5% of pregnant women take antidepressants. Studies on prenatal exposure to antidepressants reported no association with child cognition, and inconsistent results with motor function and language development. A limitation has been the failure to adjust for prenatal mater...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687276/ https://www.ncbi.nlm.nih.gov/pubmed/38035027 http://dx.doi.org/10.3389/fphar.2023.1252251 |
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author | Tanguay, Noémie Abdelouahab, Nadia Simard, Marie-Noelle Séguin, Jean R. Marc, Isabelle Herba, Catherine M. MacLeod, Andrea A. N. Courtemanche, Yohann Fraser, William D. Muckle, Gina |
author_facet | Tanguay, Noémie Abdelouahab, Nadia Simard, Marie-Noelle Séguin, Jean R. Marc, Isabelle Herba, Catherine M. MacLeod, Andrea A. N. Courtemanche, Yohann Fraser, William D. Muckle, Gina |
author_sort | Tanguay, Noémie |
collection | PubMed |
description | Introduction: Approximately 5.5% of pregnant women take antidepressants. Studies on prenatal exposure to antidepressants reported no association with child cognition, and inconsistent results with motor function and language development. A limitation has been the failure to adjust for prenatal maternal distress. Objectives: Assess the associations between prenatal exposure to antidepressants and child development at age two, while adjusting for maternal depressive symptoms and stress during pregnancy. Explore indirect effects through birth complications and consider sex-specific associations. Methods: This is an ancillary study of the 3D (Design Develop, Discover) Study initiated during pregnancy. Data on antidepressants were collected through medication logs spanning the entire pregnancy. Depressive symptoms and stress were assessed during pregnancy by self-reported questionnaires, motor and cognitive development with the Bayley Scales of Infant and Toddler Development (BSID-III), and language development with the MacArthur Communicative Development Inventories at age 2. Multiple linear regressions were used to assess the associations between exposure and developmental outcomes. Mediation models were used to assess indirect effects. Interaction terms were introduced to assess sex-specific associations. Results: 1,489 mother-child dyads were included, of whom 61 (4.1%) reported prenatal antidepressant use. Prenatal exposure was negatively associated with motor development (B = −0.91, 95% CI -1.73, −0.09 for fine motor, B = −0.89, 95% CI -1.81, 0.02 for gross motor), but not with cognitive (B = −0.53, 95% CI -1.82, 0.72) and language (B = 4.13, 95% CI -3.72, 11.89) development. Adjusting for maternal prenatal distress only slightly modified these associations. No indirect effect or differential effect according to child sex were found. Conclusion: This study supports evidence of a negative association between prenatal exposure to antidepressants and motor development at age two, after adjusting for maternal distress, but the effect size remains very small, with about only one BSID-III point lower in average. |
format | Online Article Text |
id | pubmed-10687276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106872762023-11-30 Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study Tanguay, Noémie Abdelouahab, Nadia Simard, Marie-Noelle Séguin, Jean R. Marc, Isabelle Herba, Catherine M. MacLeod, Andrea A. N. Courtemanche, Yohann Fraser, William D. Muckle, Gina Front Pharmacol Pharmacology Introduction: Approximately 5.5% of pregnant women take antidepressants. Studies on prenatal exposure to antidepressants reported no association with child cognition, and inconsistent results with motor function and language development. A limitation has been the failure to adjust for prenatal maternal distress. Objectives: Assess the associations between prenatal exposure to antidepressants and child development at age two, while adjusting for maternal depressive symptoms and stress during pregnancy. Explore indirect effects through birth complications and consider sex-specific associations. Methods: This is an ancillary study of the 3D (Design Develop, Discover) Study initiated during pregnancy. Data on antidepressants were collected through medication logs spanning the entire pregnancy. Depressive symptoms and stress were assessed during pregnancy by self-reported questionnaires, motor and cognitive development with the Bayley Scales of Infant and Toddler Development (BSID-III), and language development with the MacArthur Communicative Development Inventories at age 2. Multiple linear regressions were used to assess the associations between exposure and developmental outcomes. Mediation models were used to assess indirect effects. Interaction terms were introduced to assess sex-specific associations. Results: 1,489 mother-child dyads were included, of whom 61 (4.1%) reported prenatal antidepressant use. Prenatal exposure was negatively associated with motor development (B = −0.91, 95% CI -1.73, −0.09 for fine motor, B = −0.89, 95% CI -1.81, 0.02 for gross motor), but not with cognitive (B = −0.53, 95% CI -1.82, 0.72) and language (B = 4.13, 95% CI -3.72, 11.89) development. Adjusting for maternal prenatal distress only slightly modified these associations. No indirect effect or differential effect according to child sex were found. Conclusion: This study supports evidence of a negative association between prenatal exposure to antidepressants and motor development at age two, after adjusting for maternal distress, but the effect size remains very small, with about only one BSID-III point lower in average. Frontiers Media S.A. 2023-11-16 /pmc/articles/PMC10687276/ /pubmed/38035027 http://dx.doi.org/10.3389/fphar.2023.1252251 Text en Copyright © 2023 Tanguay, Abdelouahab, Simard, Séguin, Marc, Herba, MacLeod, Courtemanche, Fraser and Muckle. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Tanguay, Noémie Abdelouahab, Nadia Simard, Marie-Noelle Séguin, Jean R. Marc, Isabelle Herba, Catherine M. MacLeod, Andrea A. N. Courtemanche, Yohann Fraser, William D. Muckle, Gina Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study |
title | Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study |
title_full | Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study |
title_fullStr | Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study |
title_full_unstemmed | Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study |
title_short | Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study |
title_sort | antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—results from the 3d cohort study |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687276/ https://www.ncbi.nlm.nih.gov/pubmed/38035027 http://dx.doi.org/10.3389/fphar.2023.1252251 |
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