Salvage Therapy With Selpercatinib for RET-Rearranged NSCLC With Pralsetinib-Related Pneumonitis and Leptomeningeal Disease: A Case Report

Selpercatinib and pralsetinib are RET inhibitors with substantial activity in advanced RET-rearranged NSCLC. We present a case of pralsetinib-related pneumonitis and leptomeningeal and brain metastases progression during treatment suspension for pneumonitis. During recovery, selpercatinib administra...

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Autores principales: d'Arienzo, Paolo D., Cunningham, Niamh, O’Sullivan, Hazel, Grieco, Charlotte, Patel, Virjen, Popat, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687334/
https://www.ncbi.nlm.nih.gov/pubmed/38034820
http://dx.doi.org/10.1016/j.jtocrr.2023.100581
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author d'Arienzo, Paolo D.
Cunningham, Niamh
O’Sullivan, Hazel
Grieco, Charlotte
Patel, Virjen
Popat, Sanjay
author_facet d'Arienzo, Paolo D.
Cunningham, Niamh
O’Sullivan, Hazel
Grieco, Charlotte
Patel, Virjen
Popat, Sanjay
author_sort d'Arienzo, Paolo D.
collection PubMed
description Selpercatinib and pralsetinib are RET inhibitors with substantial activity in advanced RET-rearranged NSCLC. We present a case of pralsetinib-related pneumonitis and leptomeningeal and brain metastases progression during treatment suspension for pneumonitis. During recovery, selpercatinib administration led to rapid neurologic response and complete intracranial response and allowed pneumonitis resolution. This case supports the safety of selpercatinib in patients with pneumonitis on pralsetinib and highlights its marked efficacy in leptomeningeal disease.
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spelling pubmed-106873342023-11-30 Salvage Therapy With Selpercatinib for RET-Rearranged NSCLC With Pralsetinib-Related Pneumonitis and Leptomeningeal Disease: A Case Report d'Arienzo, Paolo D. Cunningham, Niamh O’Sullivan, Hazel Grieco, Charlotte Patel, Virjen Popat, Sanjay JTO Clin Res Rep Case Report Selpercatinib and pralsetinib are RET inhibitors with substantial activity in advanced RET-rearranged NSCLC. We present a case of pralsetinib-related pneumonitis and leptomeningeal and brain metastases progression during treatment suspension for pneumonitis. During recovery, selpercatinib administration led to rapid neurologic response and complete intracranial response and allowed pneumonitis resolution. This case supports the safety of selpercatinib in patients with pneumonitis on pralsetinib and highlights its marked efficacy in leptomeningeal disease. Elsevier 2023-09-29 /pmc/articles/PMC10687334/ /pubmed/38034820 http://dx.doi.org/10.1016/j.jtocrr.2023.100581 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
d'Arienzo, Paolo D.
Cunningham, Niamh
O’Sullivan, Hazel
Grieco, Charlotte
Patel, Virjen
Popat, Sanjay
Salvage Therapy With Selpercatinib for RET-Rearranged NSCLC With Pralsetinib-Related Pneumonitis and Leptomeningeal Disease: A Case Report
title Salvage Therapy With Selpercatinib for RET-Rearranged NSCLC With Pralsetinib-Related Pneumonitis and Leptomeningeal Disease: A Case Report
title_full Salvage Therapy With Selpercatinib for RET-Rearranged NSCLC With Pralsetinib-Related Pneumonitis and Leptomeningeal Disease: A Case Report
title_fullStr Salvage Therapy With Selpercatinib for RET-Rearranged NSCLC With Pralsetinib-Related Pneumonitis and Leptomeningeal Disease: A Case Report
title_full_unstemmed Salvage Therapy With Selpercatinib for RET-Rearranged NSCLC With Pralsetinib-Related Pneumonitis and Leptomeningeal Disease: A Case Report
title_short Salvage Therapy With Selpercatinib for RET-Rearranged NSCLC With Pralsetinib-Related Pneumonitis and Leptomeningeal Disease: A Case Report
title_sort salvage therapy with selpercatinib for ret-rearranged nsclc with pralsetinib-related pneumonitis and leptomeningeal disease: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687334/
https://www.ncbi.nlm.nih.gov/pubmed/38034820
http://dx.doi.org/10.1016/j.jtocrr.2023.100581
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