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Loss of CFTR function in macrophages alters the cell transcriptional program and delays lung resolution of inflammation

Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the CF Transmembrane-conductance Regulator (CFTR) gene. The most severe pathologies of CF occur in the lung, manifesting as chronic bacterial infection, persistent neutrophilic inflammation, and mucopurulent airwa...

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Detalles Bibliográficos
Autores principales:	Wellems, Dianne, Hu, Yawen, Jennings, Scott, Wang, Guoshun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687418/ https://www.ncbi.nlm.nih.gov/pubmed/38035088 http://dx.doi.org/10.3389/fimmu.2023.1242381

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