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GPR35 acts a dual role and therapeutic target in inflammation
GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory responses. Although the precise role of GPR35 in inflammation is not yet fully understood, studies have suggested that it may have both pro- and anti-inflammatory effects depending on the specific cellular envi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687457/ https://www.ncbi.nlm.nih.gov/pubmed/38035084 http://dx.doi.org/10.3389/fimmu.2023.1254446 |
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author | Wu, Yetian Zhang, Pei Fan, Hongjie Zhang, Caiying Yu, Pengfei Liang, Xinmiao Chen, Yang |
author_facet | Wu, Yetian Zhang, Pei Fan, Hongjie Zhang, Caiying Yu, Pengfei Liang, Xinmiao Chen, Yang |
author_sort | Wu, Yetian |
collection | PubMed |
description | GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory responses. Although the precise role of GPR35 in inflammation is not yet fully understood, studies have suggested that it may have both pro- and anti-inflammatory effects depending on the specific cellular environment. Some studies have shown that GPR35 activation can stimulate the production of pro-inflammatory cytokines and facilitate the movement of immune cells towards inflammatory tissues or infected areas. Conversely, other investigations have suggested that GPR35 may possess anti-inflammatory properties in the gastrointestinal tract, liver and certain other tissues by curbing the generation of inflammatory mediators and endorsing the differentiation of regulatory T cells. The intricate role of GPR35 in inflammation underscores the requirement for more in-depth research to thoroughly comprehend its functional mechanisms and its potential significance as a therapeutic target for inflammatory diseases. The purpose of this review is to concurrently investigate the pro-inflammatory and anti-inflammatory roles of GPR35, thus illuminating both facets of this complex issue. |
format | Online Article Text |
id | pubmed-10687457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106874572023-11-30 GPR35 acts a dual role and therapeutic target in inflammation Wu, Yetian Zhang, Pei Fan, Hongjie Zhang, Caiying Yu, Pengfei Liang, Xinmiao Chen, Yang Front Immunol Immunology GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory responses. Although the precise role of GPR35 in inflammation is not yet fully understood, studies have suggested that it may have both pro- and anti-inflammatory effects depending on the specific cellular environment. Some studies have shown that GPR35 activation can stimulate the production of pro-inflammatory cytokines and facilitate the movement of immune cells towards inflammatory tissues or infected areas. Conversely, other investigations have suggested that GPR35 may possess anti-inflammatory properties in the gastrointestinal tract, liver and certain other tissues by curbing the generation of inflammatory mediators and endorsing the differentiation of regulatory T cells. The intricate role of GPR35 in inflammation underscores the requirement for more in-depth research to thoroughly comprehend its functional mechanisms and its potential significance as a therapeutic target for inflammatory diseases. The purpose of this review is to concurrently investigate the pro-inflammatory and anti-inflammatory roles of GPR35, thus illuminating both facets of this complex issue. Frontiers Media S.A. 2023-11-16 /pmc/articles/PMC10687457/ /pubmed/38035084 http://dx.doi.org/10.3389/fimmu.2023.1254446 Text en Copyright © 2023 Wu, Zhang, Fan, Zhang, Yu, Liang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wu, Yetian Zhang, Pei Fan, Hongjie Zhang, Caiying Yu, Pengfei Liang, Xinmiao Chen, Yang GPR35 acts a dual role and therapeutic target in inflammation |
title | GPR35 acts a dual role and therapeutic target in inflammation |
title_full | GPR35 acts a dual role and therapeutic target in inflammation |
title_fullStr | GPR35 acts a dual role and therapeutic target in inflammation |
title_full_unstemmed | GPR35 acts a dual role and therapeutic target in inflammation |
title_short | GPR35 acts a dual role and therapeutic target in inflammation |
title_sort | gpr35 acts a dual role and therapeutic target in inflammation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687457/ https://www.ncbi.nlm.nih.gov/pubmed/38035084 http://dx.doi.org/10.3389/fimmu.2023.1254446 |
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