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The genetic and environmental contributions to variation in the permanent dental arch form: a twin study

OBJECTIVE: The objective of this study was to examine the relative contributions of genetic and environmental influences on variation in dental arch form in individuals who have largely completed their craniofacial growth. MATERIAL AND METHODS: The subjects of this study comprised dental casts of 50...

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Autores principales: Lin, Ting-han, Hughes, Toby, Meade, Maurice J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687508/
https://www.ncbi.nlm.nih.gov/pubmed/37861389
http://dx.doi.org/10.1093/ejo/cjad054
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author Lin, Ting-han
Hughes, Toby
Meade, Maurice J
author_facet Lin, Ting-han
Hughes, Toby
Meade, Maurice J
author_sort Lin, Ting-han
collection PubMed
description OBJECTIVE: The objective of this study was to examine the relative contributions of genetic and environmental influences on variation in dental arch form in individuals who have largely completed their craniofacial growth. MATERIAL AND METHODS: The subjects of this study comprised dental casts of 50 monozygotic twins and 24 dizygotic twins from the collection of records of twins housed at the Adelaide Dental School, Australia. The subjects were of Western European descent, with an average age of 20.93 ± 5.58 years. Dental casts were scanned using a 3D scanner to analyse the dental arch form. Landmark-based inter-arch and intra-arch measurements were performed. Structural equation modelling was employed to analyse the quantitative data using the normal assumptions of the twin model. RESULTS: Genetic modelling revealed that additive genetic and unique environmental factors best explained the observed variation for all occlusal traits measured, except for mandibular intercanine width. High heritability was observed for most intra-arch occlusal variables (0.61–0.85) including the maxillary and mandibular intercanine and intermolar widths, arch depth and perimeter. In contrast, moderate heritability was found for inter-arch occlusal variables (0.52–0.59) such as overjet and overbite. Sexual dimorphism was evident, with males displaying larger posterior arch width than females (P < 0.05). LIMITATIONS: Our sample was limited to individuals of Western European ancestry. CONCLUSION: The predominant source of occlusal variation within this group of Australian twins of Western European descent was controlled by genetic effects, and most were highly heritable. Generally, intra-arch occlusal variables showed greater heritability compared with inter-arch occlusal variables.
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spelling pubmed-106875082023-12-01 The genetic and environmental contributions to variation in the permanent dental arch form: a twin study Lin, Ting-han Hughes, Toby Meade, Maurice J Eur J Orthod Original Article OBJECTIVE: The objective of this study was to examine the relative contributions of genetic and environmental influences on variation in dental arch form in individuals who have largely completed their craniofacial growth. MATERIAL AND METHODS: The subjects of this study comprised dental casts of 50 monozygotic twins and 24 dizygotic twins from the collection of records of twins housed at the Adelaide Dental School, Australia. The subjects were of Western European descent, with an average age of 20.93 ± 5.58 years. Dental casts were scanned using a 3D scanner to analyse the dental arch form. Landmark-based inter-arch and intra-arch measurements were performed. Structural equation modelling was employed to analyse the quantitative data using the normal assumptions of the twin model. RESULTS: Genetic modelling revealed that additive genetic and unique environmental factors best explained the observed variation for all occlusal traits measured, except for mandibular intercanine width. High heritability was observed for most intra-arch occlusal variables (0.61–0.85) including the maxillary and mandibular intercanine and intermolar widths, arch depth and perimeter. In contrast, moderate heritability was found for inter-arch occlusal variables (0.52–0.59) such as overjet and overbite. Sexual dimorphism was evident, with males displaying larger posterior arch width than females (P < 0.05). LIMITATIONS: Our sample was limited to individuals of Western European ancestry. CONCLUSION: The predominant source of occlusal variation within this group of Australian twins of Western European descent was controlled by genetic effects, and most were highly heritable. Generally, intra-arch occlusal variables showed greater heritability compared with inter-arch occlusal variables. Oxford University Press 2023-10-20 /pmc/articles/PMC10687508/ /pubmed/37861389 http://dx.doi.org/10.1093/ejo/cjad054 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Orthodontic Society https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Lin, Ting-han
Hughes, Toby
Meade, Maurice J
The genetic and environmental contributions to variation in the permanent dental arch form: a twin study
title The genetic and environmental contributions to variation in the permanent dental arch form: a twin study
title_full The genetic and environmental contributions to variation in the permanent dental arch form: a twin study
title_fullStr The genetic and environmental contributions to variation in the permanent dental arch form: a twin study
title_full_unstemmed The genetic and environmental contributions to variation in the permanent dental arch form: a twin study
title_short The genetic and environmental contributions to variation in the permanent dental arch form: a twin study
title_sort genetic and environmental contributions to variation in the permanent dental arch form: a twin study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687508/
https://www.ncbi.nlm.nih.gov/pubmed/37861389
http://dx.doi.org/10.1093/ejo/cjad054
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