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Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment

Inconsistent findings have been reported regarding the associations between hypertensive disorders in pregnancy (HDP) and infant neurodevelopment. Leveraging data from the Jiangsu Birth Cohort, in the present study, we re-visited such associations in one-year-old infants from 2576 singleton pregnanc...

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Autores principales: Huang, Bo, Wang, Yifan, Jiang, Yangqian, Lv, Hong, Jiang, Tao, Qiu, Yun, Lu, Qun, Du, Jiangbo, Lin, Yuan, Ma, Hongxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687531/
https://www.ncbi.nlm.nih.gov/pubmed/37767602
http://dx.doi.org/10.7555/JBR.37.20230074
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author Huang, Bo
Wang, Yifan
Jiang, Yangqian
Lv, Hong
Jiang, Tao
Qiu, Yun
Lu, Qun
Du, Jiangbo
Lin, Yuan
Ma, Hongxia
author_facet Huang, Bo
Wang, Yifan
Jiang, Yangqian
Lv, Hong
Jiang, Tao
Qiu, Yun
Lu, Qun
Du, Jiangbo
Lin, Yuan
Ma, Hongxia
author_sort Huang, Bo
collection PubMed
description Inconsistent findings have been reported regarding the associations between hypertensive disorders in pregnancy (HDP) and infant neurodevelopment. Leveraging data from the Jiangsu Birth Cohort, in the present study, we re-visited such associations in one-year-old infants from 2576 singleton pregnancies and 261 twin pregnancies. We first assessed infant neurodevelopment by the Bayley Scales of Infant and Toddler Development Screening Test (the Third Edition), and then estimated its association with maternal HDP using general linear regression models and Poisson regression models. In singleton pregnancies, compared with mothers unexposed to HDP, infants born to mothers with chronic hypertension exhibited a lower score ( β, −0.67; 95% confidence interval [CI], −1.19–−0.15) and a higher risk of "non-optimal" gross motor development (risk ratio [RR], 2.21; 95% CI, 1.02–4.79); in twin pregnancies, infants born to mothers with HDP exhibited lower scores in cognition ( β, −0.49; 95% CI, −0.96–−0.01), receptive communication ( β, −0.55; 95% CI, −1.03–−0.06), and gross motor ( β, −0.44; 95% CI, −0.86–−0.03), and at a higher risk of "non-optimal" gross motor development (RR, 2.12; 95% CI, 1.16–3.88). These findings indicate that infants born to mothers with HDP may have inferior neurodevelopment outcomes at the age of one year.
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spelling pubmed-106875312023-12-01 Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment Huang, Bo Wang, Yifan Jiang, Yangqian Lv, Hong Jiang, Tao Qiu, Yun Lu, Qun Du, Jiangbo Lin, Yuan Ma, Hongxia J Biomed Res Original Article Inconsistent findings have been reported regarding the associations between hypertensive disorders in pregnancy (HDP) and infant neurodevelopment. Leveraging data from the Jiangsu Birth Cohort, in the present study, we re-visited such associations in one-year-old infants from 2576 singleton pregnancies and 261 twin pregnancies. We first assessed infant neurodevelopment by the Bayley Scales of Infant and Toddler Development Screening Test (the Third Edition), and then estimated its association with maternal HDP using general linear regression models and Poisson regression models. In singleton pregnancies, compared with mothers unexposed to HDP, infants born to mothers with chronic hypertension exhibited a lower score ( β, −0.67; 95% confidence interval [CI], −1.19–−0.15) and a higher risk of "non-optimal" gross motor development (risk ratio [RR], 2.21; 95% CI, 1.02–4.79); in twin pregnancies, infants born to mothers with HDP exhibited lower scores in cognition ( β, −0.49; 95% CI, −0.96–−0.01), receptive communication ( β, −0.55; 95% CI, −1.03–−0.06), and gross motor ( β, −0.44; 95% CI, −0.86–−0.03), and at a higher risk of "non-optimal" gross motor development (RR, 2.12; 95% CI, 1.16–3.88). These findings indicate that infants born to mothers with HDP may have inferior neurodevelopment outcomes at the age of one year. Editorial Department of Journal of Biomedical Research 2023-11 2023-09-28 /pmc/articles/PMC10687531/ /pubmed/37767602 http://dx.doi.org/10.7555/JBR.37.20230074 Text en © 2023 by the Journal of Biomedical Research. https://creativecommons.org/licenses/by/4.0/This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited.
spellingShingle Original Article
Huang, Bo
Wang, Yifan
Jiang, Yangqian
Lv, Hong
Jiang, Tao
Qiu, Yun
Lu, Qun
Du, Jiangbo
Lin, Yuan
Ma, Hongxia
Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment
title Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment
title_full Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment
title_fullStr Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment
title_full_unstemmed Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment
title_short Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment
title_sort association of maternal hypertensive disorders in pregnancy with infant neurodevelopment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687531/
https://www.ncbi.nlm.nih.gov/pubmed/37767602
http://dx.doi.org/10.7555/JBR.37.20230074
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