Cargando…

Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder. Observational studies on the relationship between leukocyte telomere length (LTL) and EMs have shown conflicting results. The purpose of this study was to evaluate the precise causal relationship between LTL and EMs using Mendelian...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Chenxue, Shen, Zixiong, Qiu, Binxu, Zhang, Songling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687575/
https://www.ncbi.nlm.nih.gov/pubmed/38034012
http://dx.doi.org/10.3389/fendo.2023.1272200
_version_ 1785152005910560768
author Bai, Chenxue
Shen, Zixiong
Qiu, Binxu
Zhang, Songling
author_facet Bai, Chenxue
Shen, Zixiong
Qiu, Binxu
Zhang, Songling
author_sort Bai, Chenxue
collection PubMed
description BACKGROUND: Endometriosis (EMs) is a common gynecological disorder. Observational studies on the relationship between leukocyte telomere length (LTL) and EMs have shown conflicting results. The purpose of this study was to evaluate the precise causal relationship between LTL and EMs using Mendelian randomization (MR) methodology. METHODS: We employed MR to assess the causal relationship between LTL and EMs. Summary data from several large-scale genome-wide association studies (GWAS) were used for bidirectional two-sample MR analysis. Sensitivity analyses were conducted to ensure the robustness of our results. All analyses were also replicated in another completely independent EMs dataset. RESULTS: Our MR analysis indicated that genetically predicted longer LTL increased the risk of EMs (IVW: discovery, OR=1.169, 95%CI: 1.059-1.290, p=0.002; validation, OR=1.302, 95%CI: 1.140-1.487, p=0.000), while EMs had no causal impact on LTL (IVW: discovery, OR=1.013, 95%CI: 1.000-1.027, p=0.056; IVW: validation, OR=1.005, 95%CI: 0.995-1.015, p=0.363). Causal estimates were supported by various calculation models (including MR-Egger, Weighted median, MR-PRESSO, and MR-RAPS). Heterogeneity and pleiotropy analyses also indicated robustness of the results. CONCLUSION: Our findings substantiate the idea that a genetically predicted longer LTL elevates the risk of EMs, with no influence of EMs on LTL risk. This research bolsters the causal link between LTL and EMs, overcoming the constraints of earlier observational studies. It implies that LTL may potentially function as a biomarker for EMs, opening up novel possibilities for EMs prevention and treatment.
format Online
Article
Text
id pubmed-10687575
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-106875752023-11-30 Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study Bai, Chenxue Shen, Zixiong Qiu, Binxu Zhang, Songling Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Endometriosis (EMs) is a common gynecological disorder. Observational studies on the relationship between leukocyte telomere length (LTL) and EMs have shown conflicting results. The purpose of this study was to evaluate the precise causal relationship between LTL and EMs using Mendelian randomization (MR) methodology. METHODS: We employed MR to assess the causal relationship between LTL and EMs. Summary data from several large-scale genome-wide association studies (GWAS) were used for bidirectional two-sample MR analysis. Sensitivity analyses were conducted to ensure the robustness of our results. All analyses were also replicated in another completely independent EMs dataset. RESULTS: Our MR analysis indicated that genetically predicted longer LTL increased the risk of EMs (IVW: discovery, OR=1.169, 95%CI: 1.059-1.290, p=0.002; validation, OR=1.302, 95%CI: 1.140-1.487, p=0.000), while EMs had no causal impact on LTL (IVW: discovery, OR=1.013, 95%CI: 1.000-1.027, p=0.056; IVW: validation, OR=1.005, 95%CI: 0.995-1.015, p=0.363). Causal estimates were supported by various calculation models (including MR-Egger, Weighted median, MR-PRESSO, and MR-RAPS). Heterogeneity and pleiotropy analyses also indicated robustness of the results. CONCLUSION: Our findings substantiate the idea that a genetically predicted longer LTL elevates the risk of EMs, with no influence of EMs on LTL risk. This research bolsters the causal link between LTL and EMs, overcoming the constraints of earlier observational studies. It implies that LTL may potentially function as a biomarker for EMs, opening up novel possibilities for EMs prevention and treatment. Frontiers Media S.A. 2023-11-16 /pmc/articles/PMC10687575/ /pubmed/38034012 http://dx.doi.org/10.3389/fendo.2023.1272200 Text en Copyright © 2023 Bai, Shen, Qiu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Bai, Chenxue
Shen, Zixiong
Qiu, Binxu
Zhang, Songling
Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study
title Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study
title_full Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study
title_fullStr Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study
title_full_unstemmed Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study
title_short Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study
title_sort leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample mendelian randomization study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687575/
https://www.ncbi.nlm.nih.gov/pubmed/38034012
http://dx.doi.org/10.3389/fendo.2023.1272200
work_keys_str_mv AT baichenxue leukocytetelomerelengthisassociatedwithincreasedriskofendometriosisabidirectionaltwosamplemendelianrandomizationstudy
AT shenzixiong leukocytetelomerelengthisassociatedwithincreasedriskofendometriosisabidirectionaltwosamplemendelianrandomizationstudy
AT qiubinxu leukocytetelomerelengthisassociatedwithincreasedriskofendometriosisabidirectionaltwosamplemendelianrandomizationstudy
AT zhangsongling leukocytetelomerelengthisassociatedwithincreasedriskofendometriosisabidirectionaltwosamplemendelianrandomizationstudy