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Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study
BACKGROUND: Endometriosis (EMs) is a common gynecological disorder. Observational studies on the relationship between leukocyte telomere length (LTL) and EMs have shown conflicting results. The purpose of this study was to evaluate the precise causal relationship between LTL and EMs using Mendelian...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687575/ https://www.ncbi.nlm.nih.gov/pubmed/38034012 http://dx.doi.org/10.3389/fendo.2023.1272200 |
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author | Bai, Chenxue Shen, Zixiong Qiu, Binxu Zhang, Songling |
author_facet | Bai, Chenxue Shen, Zixiong Qiu, Binxu Zhang, Songling |
author_sort | Bai, Chenxue |
collection | PubMed |
description | BACKGROUND: Endometriosis (EMs) is a common gynecological disorder. Observational studies on the relationship between leukocyte telomere length (LTL) and EMs have shown conflicting results. The purpose of this study was to evaluate the precise causal relationship between LTL and EMs using Mendelian randomization (MR) methodology. METHODS: We employed MR to assess the causal relationship between LTL and EMs. Summary data from several large-scale genome-wide association studies (GWAS) were used for bidirectional two-sample MR analysis. Sensitivity analyses were conducted to ensure the robustness of our results. All analyses were also replicated in another completely independent EMs dataset. RESULTS: Our MR analysis indicated that genetically predicted longer LTL increased the risk of EMs (IVW: discovery, OR=1.169, 95%CI: 1.059-1.290, p=0.002; validation, OR=1.302, 95%CI: 1.140-1.487, p=0.000), while EMs had no causal impact on LTL (IVW: discovery, OR=1.013, 95%CI: 1.000-1.027, p=0.056; IVW: validation, OR=1.005, 95%CI: 0.995-1.015, p=0.363). Causal estimates were supported by various calculation models (including MR-Egger, Weighted median, MR-PRESSO, and MR-RAPS). Heterogeneity and pleiotropy analyses also indicated robustness of the results. CONCLUSION: Our findings substantiate the idea that a genetically predicted longer LTL elevates the risk of EMs, with no influence of EMs on LTL risk. This research bolsters the causal link between LTL and EMs, overcoming the constraints of earlier observational studies. It implies that LTL may potentially function as a biomarker for EMs, opening up novel possibilities for EMs prevention and treatment. |
format | Online Article Text |
id | pubmed-10687575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106875752023-11-30 Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study Bai, Chenxue Shen, Zixiong Qiu, Binxu Zhang, Songling Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Endometriosis (EMs) is a common gynecological disorder. Observational studies on the relationship between leukocyte telomere length (LTL) and EMs have shown conflicting results. The purpose of this study was to evaluate the precise causal relationship between LTL and EMs using Mendelian randomization (MR) methodology. METHODS: We employed MR to assess the causal relationship between LTL and EMs. Summary data from several large-scale genome-wide association studies (GWAS) were used for bidirectional two-sample MR analysis. Sensitivity analyses were conducted to ensure the robustness of our results. All analyses were also replicated in another completely independent EMs dataset. RESULTS: Our MR analysis indicated that genetically predicted longer LTL increased the risk of EMs (IVW: discovery, OR=1.169, 95%CI: 1.059-1.290, p=0.002; validation, OR=1.302, 95%CI: 1.140-1.487, p=0.000), while EMs had no causal impact on LTL (IVW: discovery, OR=1.013, 95%CI: 1.000-1.027, p=0.056; IVW: validation, OR=1.005, 95%CI: 0.995-1.015, p=0.363). Causal estimates were supported by various calculation models (including MR-Egger, Weighted median, MR-PRESSO, and MR-RAPS). Heterogeneity and pleiotropy analyses also indicated robustness of the results. CONCLUSION: Our findings substantiate the idea that a genetically predicted longer LTL elevates the risk of EMs, with no influence of EMs on LTL risk. This research bolsters the causal link between LTL and EMs, overcoming the constraints of earlier observational studies. It implies that LTL may potentially function as a biomarker for EMs, opening up novel possibilities for EMs prevention and treatment. Frontiers Media S.A. 2023-11-16 /pmc/articles/PMC10687575/ /pubmed/38034012 http://dx.doi.org/10.3389/fendo.2023.1272200 Text en Copyright © 2023 Bai, Shen, Qiu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Bai, Chenxue Shen, Zixiong Qiu, Binxu Zhang, Songling Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study |
title | Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study |
title_full | Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study |
title_fullStr | Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study |
title_full_unstemmed | Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study |
title_short | Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study |
title_sort | leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample mendelian randomization study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687575/ https://www.ncbi.nlm.nih.gov/pubmed/38034012 http://dx.doi.org/10.3389/fendo.2023.1272200 |
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