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Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment

Residual antibiotics in nature are an important cause of antimicrobial drug resistance, and how to deal with residual β-lactam antibiotics in aqueous environments has become an urgent issue. In this work, magnetic zeolitic imidazolate frameworks-8 (ZIF-8) for immobilizing metallo-β-lactamases (MBLs)...

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Autores principales: Wang, Quanfang, Sun, Yuefeng, Zhao, Shidi, Bai, Chuqi, Cong, Zhiwei, Dong, Yalin, Wang, Taotao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687608/
https://www.ncbi.nlm.nih.gov/pubmed/38035241
http://dx.doi.org/10.1039/d3ra05973a
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author Wang, Quanfang
Sun, Yuefeng
Zhao, Shidi
Bai, Chuqi
Cong, Zhiwei
Dong, Yalin
Wang, Taotao
author_facet Wang, Quanfang
Sun, Yuefeng
Zhao, Shidi
Bai, Chuqi
Cong, Zhiwei
Dong, Yalin
Wang, Taotao
author_sort Wang, Quanfang
collection PubMed
description Residual antibiotics in nature are an important cause of antimicrobial drug resistance, and how to deal with residual β-lactam antibiotics in aqueous environments has become an urgent issue. In this work, magnetic zeolitic imidazolate frameworks-8 (ZIF-8) for immobilizing metallo-β-lactamases (MBLs), or Fe(3)O(4)@ZIF-8@MBLs, were successfully synthesized using the one-pot method in aqueous solution. The morphology and chemical structure of Fe(3)O(4)@ZIF-8@MBLs were characterized by scanning electron microscopy, energy dispersive spectra, X-ray diffraction, infrared spectra, physical adsorption, and zeta potential. Further, the degradation performance of Fe(3)O(4)@ZIF-8@MBLs for β-lactam antibiotics (penicillin G, cefoperazone, meropenem) in an aqueous environment was investigated by UV-visible absorption spectrophotometry. The results indicated that Fe(3)O(4)@ZIF-8@MBLs, compared to control ZIF-8, exhibited superior degradation ability, excellent reusability, and better stability under several harsh conditions. The strategy of combining ZIF-8 and MBLs to form magnetic porous polymers may be suitable for removing β-lactam antibiotics from an aqueous environment. This work provided an original insight into future studies on the degradation of β-lactam antibiotics employing MBLs immobilized by magnetic metal–organic frameworks.
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spelling pubmed-106876082023-11-30 Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment Wang, Quanfang Sun, Yuefeng Zhao, Shidi Bai, Chuqi Cong, Zhiwei Dong, Yalin Wang, Taotao RSC Adv Chemistry Residual antibiotics in nature are an important cause of antimicrobial drug resistance, and how to deal with residual β-lactam antibiotics in aqueous environments has become an urgent issue. In this work, magnetic zeolitic imidazolate frameworks-8 (ZIF-8) for immobilizing metallo-β-lactamases (MBLs), or Fe(3)O(4)@ZIF-8@MBLs, were successfully synthesized using the one-pot method in aqueous solution. The morphology and chemical structure of Fe(3)O(4)@ZIF-8@MBLs were characterized by scanning electron microscopy, energy dispersive spectra, X-ray diffraction, infrared spectra, physical adsorption, and zeta potential. Further, the degradation performance of Fe(3)O(4)@ZIF-8@MBLs for β-lactam antibiotics (penicillin G, cefoperazone, meropenem) in an aqueous environment was investigated by UV-visible absorption spectrophotometry. The results indicated that Fe(3)O(4)@ZIF-8@MBLs, compared to control ZIF-8, exhibited superior degradation ability, excellent reusability, and better stability under several harsh conditions. The strategy of combining ZIF-8 and MBLs to form magnetic porous polymers may be suitable for removing β-lactam antibiotics from an aqueous environment. This work provided an original insight into future studies on the degradation of β-lactam antibiotics employing MBLs immobilized by magnetic metal–organic frameworks. The Royal Society of Chemistry 2023-11-30 /pmc/articles/PMC10687608/ /pubmed/38035241 http://dx.doi.org/10.1039/d3ra05973a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wang, Quanfang
Sun, Yuefeng
Zhao, Shidi
Bai, Chuqi
Cong, Zhiwei
Dong, Yalin
Wang, Taotao
Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment
title Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment
title_full Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment
title_fullStr Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment
title_full_unstemmed Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment
title_short Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment
title_sort metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687608/
https://www.ncbi.nlm.nih.gov/pubmed/38035241
http://dx.doi.org/10.1039/d3ra05973a
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