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Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study
BACKGROUND/OBJECTIVES: Butyrylcholinesterase (BChE), a liver-derived enzyme that hydrolyzes acylated ghrelin to des-acylated ghrelin, may trigger a potential mechanism responsible for the acute exercise-induced suppression of acylated ghrelin. However, studies examining the effects of an acute bout...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Society of Chinese Scholars on Exercise Physiology and Fitness
2024
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687701/ https://www.ncbi.nlm.nih.gov/pubmed/38033619 http://dx.doi.org/10.1016/j.jesf.2023.11.001 |
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author | Li, Yibin Tataka, Yusei Sakazaki, Miki Kamemoto, Kayoko Nagayama, Chihiro Yoshikawa, Yoshie Yamada, Yoshiki Miyashita, Masashi |
author_facet | Li, Yibin Tataka, Yusei Sakazaki, Miki Kamemoto, Kayoko Nagayama, Chihiro Yoshikawa, Yoshie Yamada, Yoshiki Miyashita, Masashi |
author_sort | Li, Yibin |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: Butyrylcholinesterase (BChE), a liver-derived enzyme that hydrolyzes acylated ghrelin to des-acylated ghrelin, may trigger a potential mechanism responsible for the acute exercise-induced suppression of acylated ghrelin. However, studies examining the effects of an acute bout of high-intensity exercise on BChE and acylated ghrelin have yielded inconsistent findings. This study aimed to examine the acute effects of exercise intensity on BChE, acylated ghrelin and des-acylated ghrelin concentrations in humans. METHODS: Fifteen young men (aged 22.7 ± 1.8 years, mean ± standard deviation) completed three, half-day laboratory-based trials (i.e., high-intensity exercise, low-intensity exercise and control), in a random order. In the exercise trials, the participants ran for 60 min (from 09:30 to 10:30) at a speed eliciting 70 % (high-intensity) or 40 % (low-intensity) of their maximum oxygen uptake and then rested for 90 min. In the control trial, participants sat on a chair for the entire trial (from 09:30 to 12:00). Venous blood samples were collected at 09:30, 10:00, 10:30, 11:00, 11:30 and 12:00. RESULTS: The BChE concentration was not altered over time among the three trials. Total acylated and des-acylated ghrelin area under the curve during the first 60 min (i.e., from 0 min to 60 min) of the main trial were lower in the high-intensity exercise trial than in the control (acylated ghrelin, mean difference: 62.6 pg/mL, p < 0.001; des-acylated ghrelin, mean difference: 31.4 pg/mL, p = 0.035) and the low-intensity exercise trial (acylated ghrelin, mean difference: 87.7 pg/mL, p < 0.001; des-acylated ghrelin, mean difference: 43.0 pg/mL, p = 0.042). CONCLUSION: The findings suggest that BChE may not be involved in the modulation of ghrelin even though lowered acylated ghrelin concentration was observed after high-intensity exercise. |
format | Online Article Text |
id | pubmed-10687701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2024 |
publisher | The Society of Chinese Scholars on Exercise Physiology and Fitness |
record_format | MEDLINE/PubMed |
spelling | pubmed-106877012023-11-30 Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study Li, Yibin Tataka, Yusei Sakazaki, Miki Kamemoto, Kayoko Nagayama, Chihiro Yoshikawa, Yoshie Yamada, Yoshiki Miyashita, Masashi J Exerc Sci Fit Article BACKGROUND/OBJECTIVES: Butyrylcholinesterase (BChE), a liver-derived enzyme that hydrolyzes acylated ghrelin to des-acylated ghrelin, may trigger a potential mechanism responsible for the acute exercise-induced suppression of acylated ghrelin. However, studies examining the effects of an acute bout of high-intensity exercise on BChE and acylated ghrelin have yielded inconsistent findings. This study aimed to examine the acute effects of exercise intensity on BChE, acylated ghrelin and des-acylated ghrelin concentrations in humans. METHODS: Fifteen young men (aged 22.7 ± 1.8 years, mean ± standard deviation) completed three, half-day laboratory-based trials (i.e., high-intensity exercise, low-intensity exercise and control), in a random order. In the exercise trials, the participants ran for 60 min (from 09:30 to 10:30) at a speed eliciting 70 % (high-intensity) or 40 % (low-intensity) of their maximum oxygen uptake and then rested for 90 min. In the control trial, participants sat on a chair for the entire trial (from 09:30 to 12:00). Venous blood samples were collected at 09:30, 10:00, 10:30, 11:00, 11:30 and 12:00. RESULTS: The BChE concentration was not altered over time among the three trials. Total acylated and des-acylated ghrelin area under the curve during the first 60 min (i.e., from 0 min to 60 min) of the main trial were lower in the high-intensity exercise trial than in the control (acylated ghrelin, mean difference: 62.6 pg/mL, p < 0.001; des-acylated ghrelin, mean difference: 31.4 pg/mL, p = 0.035) and the low-intensity exercise trial (acylated ghrelin, mean difference: 87.7 pg/mL, p < 0.001; des-acylated ghrelin, mean difference: 43.0 pg/mL, p = 0.042). CONCLUSION: The findings suggest that BChE may not be involved in the modulation of ghrelin even though lowered acylated ghrelin concentration was observed after high-intensity exercise. The Society of Chinese Scholars on Exercise Physiology and Fitness 2024-01 2023-11-20 /pmc/articles/PMC10687701/ /pubmed/38033619 http://dx.doi.org/10.1016/j.jesf.2023.11.001 Text en © 2023 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier (Singapore) Pte Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Li, Yibin Tataka, Yusei Sakazaki, Miki Kamemoto, Kayoko Nagayama, Chihiro Yoshikawa, Yoshie Yamada, Yoshiki Miyashita, Masashi Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
title | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
title_full | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
title_fullStr | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
title_full_unstemmed | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
title_short | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
title_sort | acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: a randomized controlled study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687701/ https://www.ncbi.nlm.nih.gov/pubmed/38033619 http://dx.doi.org/10.1016/j.jesf.2023.11.001 |
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