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Therapy challenges for NMOSD in a patient with HIV
Neuromyelitis optica spectrum disorder (NMOSD) in people living with HIV (PLWH) is rare and its management can be difficult. Here we report a case of an HIV patient with bilateral vision loss, who was diagnosed with AQP4-IgG-positive NMOSD in 2020 during the COVID-19 pandemic. Rituximab treatment wa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687800/ https://www.ncbi.nlm.nih.gov/pubmed/37712413 http://dx.doi.org/10.1177/13524585231199022 |
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author | Engels, Daniel Havla, Joachim Förderreuther, Stefanie Kümpfel, Tania |
author_facet | Engels, Daniel Havla, Joachim Förderreuther, Stefanie Kümpfel, Tania |
author_sort | Engels, Daniel |
collection | PubMed |
description | Neuromyelitis optica spectrum disorder (NMOSD) in people living with HIV (PLWH) is rare and its management can be difficult. Here we report a case of an HIV patient with bilateral vision loss, who was diagnosed with AQP4-IgG-positive NMOSD in 2020 during the COVID-19 pandemic. Rituximab treatment was initiated after attack therapy with corticosteroids and plasma exchange. NMOSD and HIV disease remained stable, but SARS-CoV-2 immune response after repeated vaccinations was insufficient. After switching immunotherapy due to the lack of vaccination response to satralizumab, peripheral B cells reoccurred and a humoral immune response was observed after reapplication of SARS-CoV-2 vaccination. This case illustrates the challenges associated with the treatment of NMOSD in PLWH. |
format | Online Article Text |
id | pubmed-10687800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-106878002023-12-01 Therapy challenges for NMOSD in a patient with HIV Engels, Daniel Havla, Joachim Förderreuther, Stefanie Kümpfel, Tania Mult Scler Case Report Neuromyelitis optica spectrum disorder (NMOSD) in people living with HIV (PLWH) is rare and its management can be difficult. Here we report a case of an HIV patient with bilateral vision loss, who was diagnosed with AQP4-IgG-positive NMOSD in 2020 during the COVID-19 pandemic. Rituximab treatment was initiated after attack therapy with corticosteroids and plasma exchange. NMOSD and HIV disease remained stable, but SARS-CoV-2 immune response after repeated vaccinations was insufficient. After switching immunotherapy due to the lack of vaccination response to satralizumab, peripheral B cells reoccurred and a humoral immune response was observed after reapplication of SARS-CoV-2 vaccination. This case illustrates the challenges associated with the treatment of NMOSD in PLWH. SAGE Publications 2023-09-15 2023-12 /pmc/articles/PMC10687800/ /pubmed/37712413 http://dx.doi.org/10.1177/13524585231199022 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Engels, Daniel Havla, Joachim Förderreuther, Stefanie Kümpfel, Tania Therapy challenges for NMOSD in a patient with HIV |
title | Therapy challenges for NMOSD in a patient with HIV |
title_full | Therapy challenges for NMOSD in a patient with HIV |
title_fullStr | Therapy challenges for NMOSD in a patient with HIV |
title_full_unstemmed | Therapy challenges for NMOSD in a patient with HIV |
title_short | Therapy challenges for NMOSD in a patient with HIV |
title_sort | therapy challenges for nmosd in a patient with hiv |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687800/ https://www.ncbi.nlm.nih.gov/pubmed/37712413 http://dx.doi.org/10.1177/13524585231199022 |
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