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Structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm
Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics. Interindividual variability in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687969/ https://www.ncbi.nlm.nih.gov/pubmed/38019107 http://dx.doi.org/10.1177/03000605231214065 |
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author | Thabet, Romany H. Alshar, Bayan Osama Shehadeh Alabdallah, Doaa Habes Saleh Alhmoud, Nour Alhuda Zaid Ahmad Alslameen, Sondos Taher Abdalsalam Thabet, Youssef Romany Helmy |
author_facet | Thabet, Romany H. Alshar, Bayan Osama Shehadeh Alabdallah, Doaa Habes Saleh Alhmoud, Nour Alhuda Zaid Ahmad Alslameen, Sondos Taher Abdalsalam Thabet, Youssef Romany Helmy |
author_sort | Thabet, Romany H. |
collection | PubMed |
description | Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics. Interindividual variability in drug response and adverse effects is mainly attributable to genetic variation in enzymes such as sulfotransferases and cytochrome P450s. The current narrative review discusses the relationship between the structure and activity of drugs. Specifically, the activity of drugs can be increased and/or their adverse effects can be reduced by altering specific positions in their structures. |
format | Online Article Text |
id | pubmed-10687969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-106879692023-11-30 Structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm Thabet, Romany H. Alshar, Bayan Osama Shehadeh Alabdallah, Doaa Habes Saleh Alhmoud, Nour Alhuda Zaid Ahmad Alslameen, Sondos Taher Abdalsalam Thabet, Youssef Romany Helmy J Int Med Res Narrative Review Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics. Interindividual variability in drug response and adverse effects is mainly attributable to genetic variation in enzymes such as sulfotransferases and cytochrome P450s. The current narrative review discusses the relationship between the structure and activity of drugs. Specifically, the activity of drugs can be increased and/or their adverse effects can be reduced by altering specific positions in their structures. SAGE Publications 2023-11-29 /pmc/articles/PMC10687969/ /pubmed/38019107 http://dx.doi.org/10.1177/03000605231214065 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Narrative Review Thabet, Romany H. Alshar, Bayan Osama Shehadeh Alabdallah, Doaa Habes Saleh Alhmoud, Nour Alhuda Zaid Ahmad Alslameen, Sondos Taher Abdalsalam Thabet, Youssef Romany Helmy Structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm |
title | Structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm |
title_full | Structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm |
title_fullStr | Structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm |
title_full_unstemmed | Structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm |
title_short | Structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm |
title_sort | structure–activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm |
topic | Narrative Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687969/ https://www.ncbi.nlm.nih.gov/pubmed/38019107 http://dx.doi.org/10.1177/03000605231214065 |
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