Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023

We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, th...

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Autores principales: Maubaret, Clara, Caméléna, François, Mrimèche, Manel, Braille, Aymeric, Liberge, Mathilde, Mainardis, Mary, Guillaume, Clémence, Noel, Franck, Bébéar, Cécile, Molina, Jean-Michel, Lot, Florence, Chazelle, Emilie, Berçot, Béatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687985/
https://www.ncbi.nlm.nih.gov/pubmed/37707979
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.37.2300456
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author Maubaret, Clara
Caméléna, François
Mrimèche, Manel
Braille, Aymeric
Liberge, Mathilde
Mainardis, Mary
Guillaume, Clémence
Noel, Franck
Bébéar, Cécile
Molina, Jean-Michel
Lot, Florence
Chazelle, Emilie
Berçot, Béatrice
author_facet Maubaret, Clara
Caméléna, François
Mrimèche, Manel
Braille, Aymeric
Liberge, Mathilde
Mainardis, Mary
Guillaume, Clémence
Noel, Franck
Bébéar, Cécile
Molina, Jean-Michel
Lot, Florence
Chazelle, Emilie
Berçot, Béatrice
author_sort Maubaret, Clara
collection PubMed
description We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic penA-60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene. The NG isolates F93 and F94 were related to XDR isolates detected in Austria and the United Kingdom in 2022.
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spelling pubmed-106879852023-12-01 Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023 Maubaret, Clara Caméléna, François Mrimèche, Manel Braille, Aymeric Liberge, Mathilde Mainardis, Mary Guillaume, Clémence Noel, Franck Bébéar, Cécile Molina, Jean-Michel Lot, Florence Chazelle, Emilie Berçot, Béatrice Euro Surveill Rapid Communication We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic penA-60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene. The NG isolates F93 and F94 were related to XDR isolates detected in Austria and the United Kingdom in 2022. European Centre for Disease Prevention and Control (ECDC) 2023-09-14 /pmc/articles/PMC10687985/ /pubmed/37707979 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.37.2300456 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Maubaret, Clara
Caméléna, François
Mrimèche, Manel
Braille, Aymeric
Liberge, Mathilde
Mainardis, Mary
Guillaume, Clémence
Noel, Franck
Bébéar, Cécile
Molina, Jean-Michel
Lot, Florence
Chazelle, Emilie
Berçot, Béatrice
Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023
title Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023
title_full Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023
title_fullStr Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023
title_full_unstemmed Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023
title_short Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023
title_sort two cases of extensively drug-resistant (xdr) neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, france, november 2022 and may 2023
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687985/
https://www.ncbi.nlm.nih.gov/pubmed/37707979
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.37.2300456
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