Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression

BACKGROUND: T cell engagers (TCEs) have been established as an emerging modality for hematologic malignancies, but solid tumors remain refractory. However, the upregulation of programmed cell death 1 (PD-1) is correlated with T cell dysfunction that confer tumor-mediated immunosuppression. Developin...

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Detalles Bibliográficos
Autores principales: Ding, Ziqiang, Sun, Shuyang, Wang, Xuan, Yang, Xiaomei, Shi, Wei, Huang, Xianing, Xie, Shenxia, Mo, Fengzhen, Hou, Xiaoqiong, Liu, Aiqun, Jiang, Xiaobing, Tang, Zhuoran, Lu, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688028/
https://www.ncbi.nlm.nih.gov/pubmed/38031188
http://dx.doi.org/10.1186/s13045-023-01507-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688028/
https://www.ncbi.nlm.nih.gov/pubmed/38031188
http://dx.doi.org/10.1186/s13045-023-01507-4

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