CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in G(αs)-G(αi) coupling to the β(2)-adrenergic receptor

In essence, the β(2) adrenergic receptor (β(2)AR) plays an antiproliferative role by increasing the intracellular cyclic 3’,5’-adenosine monophosphate (cAMP) concentration through G(αs) coupling, but interestingly, β(2)AR antagonists are able to effectively inhibit fibroblast-like synoviocytes (FLSs...

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Detalles Bibliográficos
Autores principales: Ge, Mingli, Wu, Li, He, Feng, Tai, Yu, Fang, Ruhong, Han, Dafei, Guo, Paipai, Liu, Hao, Hu, Yong, Xu, Shenglin, Wei, Wei, Wang, Qingtong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688045/
https://www.ncbi.nlm.nih.gov/pubmed/38037039
http://dx.doi.org/10.1186/s12964-023-01358-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688045/
https://www.ncbi.nlm.nih.gov/pubmed/38037039
http://dx.doi.org/10.1186/s12964-023-01358-z

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