mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo

BACKGROUND: Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism in the body. Inhibition of mTOR signaling in early embryo causes postimplant...

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Detalles Bibliográficos
Autores principales: Ma, Chiyuan, Li, Qin, Yang, Yuxin, Ge, Lei, Cai, Jiaxuan, Wang, Juan, Zhu, Maoxian, Xiong, Yue, Zhang, Wenya, Xie, Jingtong, Cao, Yujing, Zhao, Huashan, Wei, Qing, Huang, Chen, Shi, Junchao, Zhang, Jian V., Duan, Enkui, Lei, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688112/
https://www.ncbi.nlm.nih.gov/pubmed/38037142
http://dx.doi.org/10.1186/s13578-023-01176-3

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