The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis

Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely related in the process of distant tumor metastasis. Primary tumors are shed and released into the bloodstream to form CTCs that are referred to as seeds to colonize and grow in soi...

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Autores principales: Guo, Siyin, Huang, Jing, Li, Genpeng, Chen, Wenjie, Li, Zhihui, Lei, Jianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688140/
https://www.ncbi.nlm.nih.gov/pubmed/38037077
http://dx.doi.org/10.1186/s12943-023-01909-5
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author Guo, Siyin
Huang, Jing
Li, Genpeng
Chen, Wenjie
Li, Zhihui
Lei, Jianyong
author_facet Guo, Siyin
Huang, Jing
Li, Genpeng
Chen, Wenjie
Li, Zhihui
Lei, Jianyong
author_sort Guo, Siyin
collection PubMed
description Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely related in the process of distant tumor metastasis. Primary tumors are shed and released into the bloodstream to form CTCs that are referred to as seeds to colonize and grow in soil-like distant target organs, while EVs of tumor and nontumor origin act as fertilizers in the process of tumor metastasis. There is no previous text that provides a comprehensive review of the role of EVs on CTCs during tumor metastasis. In this paper, we reviewed the mechanisms of EVs on CTCs during tumor metastasis, including the ability of EVs to enhance the shedding of CTCs, protect CTCs in circulation and determine the direction of CTC metastasis, thus affecting the distant metastasis of tumors.
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spelling pubmed-106881402023-11-30 The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis Guo, Siyin Huang, Jing Li, Genpeng Chen, Wenjie Li, Zhihui Lei, Jianyong Mol Cancer Review Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely related in the process of distant tumor metastasis. Primary tumors are shed and released into the bloodstream to form CTCs that are referred to as seeds to colonize and grow in soil-like distant target organs, while EVs of tumor and nontumor origin act as fertilizers in the process of tumor metastasis. There is no previous text that provides a comprehensive review of the role of EVs on CTCs during tumor metastasis. In this paper, we reviewed the mechanisms of EVs on CTCs during tumor metastasis, including the ability of EVs to enhance the shedding of CTCs, protect CTCs in circulation and determine the direction of CTC metastasis, thus affecting the distant metastasis of tumors. BioMed Central 2023-11-30 /pmc/articles/PMC10688140/ /pubmed/38037077 http://dx.doi.org/10.1186/s12943-023-01909-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Guo, Siyin
Huang, Jing
Li, Genpeng
Chen, Wenjie
Li, Zhihui
Lei, Jianyong
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
title The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
title_full The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
title_fullStr The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
title_full_unstemmed The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
title_short The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
title_sort role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688140/
https://www.ncbi.nlm.nih.gov/pubmed/38037077
http://dx.doi.org/10.1186/s12943-023-01909-5
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