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“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders
[Image: see text] Click chemistry is a set of easy, atom-economical reactions that are often utilized to combine two desired chemical entities. Click chemistry accelerates lead identification and optimization, reduces the complexity of chemical synthesis, and delivers extremely high yields without u...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688180/ https://www.ncbi.nlm.nih.gov/pubmed/38046293 http://dx.doi.org/10.1021/acsomega.3c04960 |
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author | Manoharan, Amritha Jayan, Jayalakshmi Rangarajan, T. M. Bose, Kuntal Benny, Feba Ipe, Reshma Susan Kumar, Sunil Kukreti, Neelima Abdelgawad, Mohamed A. Ghoneim, Mohammed M. Kim, Hoon Mathew, Bijo |
author_facet | Manoharan, Amritha Jayan, Jayalakshmi Rangarajan, T. M. Bose, Kuntal Benny, Feba Ipe, Reshma Susan Kumar, Sunil Kukreti, Neelima Abdelgawad, Mohamed A. Ghoneim, Mohammed M. Kim, Hoon Mathew, Bijo |
author_sort | Manoharan, Amritha |
collection | PubMed |
description | [Image: see text] Click chemistry is a set of easy, atom-economical reactions that are often utilized to combine two desired chemical entities. Click chemistry accelerates lead identification and optimization, reduces the complexity of chemical synthesis, and delivers extremely high yields without undesirable byproducts. The most well-known click chemistry reaction is the 1,3-dipolar cycloaddition of azides and alkynes to form 1,2,3-triazoles. The resulting 1,2,3-triazoles can serve as both bioisosteres and linkers, leading to an increase in their use in the field of drug discovery. The current Review focuses on the use of click chemistry to identify new molecules for treating neurodegenerative diseases and in other areas such as peptide targeting and the quantification of biomolecules. |
format | Online Article Text |
id | pubmed-10688180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-106881802023-12-01 “Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders Manoharan, Amritha Jayan, Jayalakshmi Rangarajan, T. M. Bose, Kuntal Benny, Feba Ipe, Reshma Susan Kumar, Sunil Kukreti, Neelima Abdelgawad, Mohamed A. Ghoneim, Mohammed M. Kim, Hoon Mathew, Bijo ACS Omega [Image: see text] Click chemistry is a set of easy, atom-economical reactions that are often utilized to combine two desired chemical entities. Click chemistry accelerates lead identification and optimization, reduces the complexity of chemical synthesis, and delivers extremely high yields without undesirable byproducts. The most well-known click chemistry reaction is the 1,3-dipolar cycloaddition of azides and alkynes to form 1,2,3-triazoles. The resulting 1,2,3-triazoles can serve as both bioisosteres and linkers, leading to an increase in their use in the field of drug discovery. The current Review focuses on the use of click chemistry to identify new molecules for treating neurodegenerative diseases and in other areas such as peptide targeting and the quantification of biomolecules. American Chemical Society 2023-11-14 /pmc/articles/PMC10688180/ /pubmed/38046293 http://dx.doi.org/10.1021/acsomega.3c04960 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Manoharan, Amritha Jayan, Jayalakshmi Rangarajan, T. M. Bose, Kuntal Benny, Feba Ipe, Reshma Susan Kumar, Sunil Kukreti, Neelima Abdelgawad, Mohamed A. Ghoneim, Mohammed M. Kim, Hoon Mathew, Bijo “Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders |
title | “Click Chemistry”: An Emerging Tool
for Developing a New Class of Structural Motifs against Various Neurodegenerative
Disorders |
title_full | “Click Chemistry”: An Emerging Tool
for Developing a New Class of Structural Motifs against Various Neurodegenerative
Disorders |
title_fullStr | “Click Chemistry”: An Emerging Tool
for Developing a New Class of Structural Motifs against Various Neurodegenerative
Disorders |
title_full_unstemmed | “Click Chemistry”: An Emerging Tool
for Developing a New Class of Structural Motifs against Various Neurodegenerative
Disorders |
title_short | “Click Chemistry”: An Emerging Tool
for Developing a New Class of Structural Motifs against Various Neurodegenerative
Disorders |
title_sort | “click chemistry”: an emerging tool
for developing a new class of structural motifs against various neurodegenerative
disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688180/ https://www.ncbi.nlm.nih.gov/pubmed/38046293 http://dx.doi.org/10.1021/acsomega.3c04960 |
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