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Deep mutational scanning reveals the functional constraints and evolutionary potential of the influenza A virus PB1 protein

The influenza virus polymerase is central to influenza virus evolution. Adaptive mutations within the polymerase are often a prerequisite for efficient spread of novel animal-derived viruses in human populations. The polymerase also determines fidelity and, therefore, the rate at which the virus wil...

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Detalles Bibliográficos
Autores principales:	Li, Yuan, Arcos, Sarah, Sabsay, Kimberly R., te Velthuis, Aartjan J. W., Lauring, Adam S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688322/ https://www.ncbi.nlm.nih.gov/pubmed/37882522 http://dx.doi.org/10.1128/jvi.01329-23

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