Characterization and biodistribution of under-employed gene therapy vector AAV7

AAV7 is a clade D adeno-associated virus (AAV) whose potential as a gene therapy vector has not been fully evaluated. We show here that high-titer AAV7 vectors can be produced in HEK293 cells and used to transduce cultured cells in an AAV receptor (AAVR)-dependent manner. In contrast with AAV9, AAV7...

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Detalles Bibliográficos
Autores principales: Yost, Samantha A., Firlar, Emre, Glenn, Justin D., Carroll, Hayley B., Foltz, Steven, Giles, April R., Egley, Jenny M., Firnberg, Elad, Cho, Sungyeon, Nguyen, Trang, Henry, William M., Janczura, Karolina J., Bruder, Joseph, Liu, Ye, Danos, Olivier, Karumuthil-Melethil, Subha, Pannem, Sanjana, Yost, Valerie, Engelson, Yelena, Kaelber, Jason T., Dimant, Hemi, Smith, Jared B., Mercer, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Gene Delivery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688378/
https://www.ncbi.nlm.nih.gov/pubmed/37843374
http://dx.doi.org/10.1128/jvi.01163-23

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